{"id":3245,"date":"2018-09-27T06:00:33","date_gmt":"2018-09-26T21:00:33","guid":{"rendered":"https:\/\/www.muscle-hypertrophy.com\/?p=3245"},"modified":"2018-09-27T16:44:42","modified_gmt":"2018-09-27T07:44:42","slug":"%e7%ad%8b%e3%83%88%e3%83%ac%e3%81%ae%e5%88%86%e5%ad%90%e7%94%9f%e7%89%a9%e5%ad%a65%e3%82%a2%e3%82%af%e3%83%81%e3%83%b3%e3%81%a8%e3%83%9f%e3%82%aa%e3%82%b7%e3%83%b3%ef%bc%8c%e3%82%bf%e3%82%a4","status":"publish","type":"post","link":"https:\/\/www.muscle-hypertrophy.com\/?p=3245","title":{"rendered":"\u7b4b\u30c8\u30ec\u306e\u5206\u5b50\u751f\u7269\u5b66(5)\u30a2\u30af\u30c1\u30f3\u3068\u30df\u30aa\u30b7\u30f3\uff0c\u30bf\u30a4\u30c1\u30f3"},"content":{"rendered":"<p>\u3000\u7b4b\u30c8\u30ec\u306e\u5206\u5b50\u751f\u7269\u5b66\u30b7\u30ea\u30fc\u30ba\u7b2c 5 \u5f3e\uff0e\u7b4b\u53ce\u7e2e\u306e\u4e3b\u4f53\u3067\u3042\u308b\u30a2\u30af\u30c1\u30f3\u3068\u30df\u30aa\u30b7\u30f3\u306b\u3064\u3044\u3066\uff0e\u30bf\u30a4\u30c1\u30f3\u306b\u3064\u3044\u3066\u6700\u8fd1\u5206\u304b\u3063\u3066\u304d\u305f\u70b9\u306b\u3082\u8a00\u53ca\u3059\u308b\uff0e<a href=\"http:\/\/www.diamondblog.jp\/official\/yoshinori_yamamoto\/\" rel=\"noopener\" target=\"_blank\">\u5c71\u672c\u7fa9\u5fb3\u30aa\u30d5\u30a3\u30b7\u30e3\u30eb\u30d6\u30ed\u30b0<\/a>\u306f\u5b66\u8853\u7684\u306b\u3082\u8a73\u7d30\u306a\u3053\u3068\u3067\u6709\u540d\u3067\u3042\u308b\u304c, 2018 \u5e74 9 \u6708 27 \u65e5\u6642\u70b9\u3067\u306f\uff0c\u30bf\u30a4\u30c1\u30f3\u306b\u3064\u3044\u3066\u306f\u53e4\u3044\u5b66\u8aac\u306e\u307e\u307e\u3067\u3042\u308b\uff0e<\/p>\n<p><iframe loading=\"lazy\" title=\"High-Speed AFM and Applications to Biomolecular Systems: Supplemental Video 4\" width=\"525\" height=\"295\" src=\"https:\/\/www.youtube.com\/embed\/0B-NYEJtdkw?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p><!--more--><\/p>\n<h3>\u7d30\u80de\u9aa8\u683c<\/h3>\n<p>\u3000\u7d30\u80de\u306e\u5f62\u614b\u3092\u7dad\u6301\u3057\u3066\u3044\u308b\u86cb\u767d\u8cea\u306b\u306f 3 \u7a2e\u985e\u3042\u308a\uff0c\u7d30\u80de\u9aa8\u683c\u3068\u547c\u3070\u308c\u308b\uff0e\u5fae\u5c0f\u7ba1\uff0c\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\uff0c\u4e2d\u9593\u5f84\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u3067\u3042\u308b\uff0e<\/p>\n<p>\u3000\u4e2d\u9593\u5f84\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306f\u6bd4\u8f03\u7684\u4e08\u592b\u306a\u30ed\u30fc\u30d7\u72b6\u306e\u69cb\u9020\u3067\uff0c\u66f2\u3052\u3084\u3059\u304f\u5207\u308c\u306b\u304f\u3044\u6027\u8cea\u3092\u6301\u3063\u3066\u3044\u308b\uff0e\u5fae\u5c0f\u7ba1\u306f\u4e08\u592b\u3067\u786c\u3044\u4e2d\u7a7a\u69cb\u9020\u3092\u3057\u3066\u3044\u308b\uff0e\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306f\u6700\u3082\u7d30\u304f\uff0c\u4f38\u3073\u306b\u304f\u304f\uff0c\u5207\u308c\u3084\u3059\u3044\u6027\u8cea\u3092\u6301\u3063\u3066\u3044\u308b\uff0e<\/p>\n<p>\u3000\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306f\u67b6\u6a4b\u86cb\u767d\u306b\u3088\u308a\u69d8\u3005\u306a\u69cb\u9020\u3092\u53d6\u308b\u304c\uff0c\u7b4b\u7d30\u80de\u306b\u304a\u3044\u3066\u306f <strong>\u03b1 \u30a2\u30af\u30c1\u30cb\u30f3<\/strong>\u306b\u3088\u308a\u6bd4\u8f03\u7684\u3086\u308b\u304f\u67b6\u6a4b\u3055\u308c\u3066\u304a\u308a\uff0c<strong>II \u578b\u30df\u30aa\u30b7\u30f3<\/strong>\u304c\u5165\u308a\u8fbc\u3080\u9699\u9593\u3092\u4f5c\u3063\u3066\u3044\u308b\uff0e<\/p>\n<h3>\u30df\u30aa\u30b7\u30f3\u6ed1\u8d70\u8aac<\/h3>\n<p>\u3000\u30a2\u30af\u30c1\u30f3\u3068\u30df\u30aa\u30b7\u30f3\u306e ATP \u52a0\u6c34\u5206\u89e3\u306b\u4f34\u3046\u529b\u767a\u751f\u306e\u7269\u7406\u7684\u539f\u7406\u306f\u5206\u304b\u3063\u3066\u3044\u306a\u3044\u304c\uff0c\u69d8\u3005\u306a\u72b6\u6cc1\u8a3c\u62e0\u304b\u3089<strong>\u30df\u30aa\u30b7\u30f3\u6ed1\u8d70\u8aac<\/strong>\u304c\u652f\u6301\u3055\u308c\u3066\u3044\u308b\uff0e<\/p>\n<p>\u3000<strong>\u30df\u30aa\u30b7\u30f3\u982d\u90e8<\/strong>\u306f ATP \u3092\u7d50\u5408\u3057\u3066\u52a0\u6c34\u5206\u89e3\u3057\uff0c\u305d\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u7528\u3044\u3066\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u4e0a\u3092\u79fb\u52d5\u3059\u308b\uff0e\u30df\u30aa\u30b7\u30f3\u306e\u4e09\u6b21\u5143\u69cb\u9020\u3092\u8abf\u3079\u3066\u307f\u308b\u3068\uff0c\u30df\u30aa\u30b7\u30f3\u982d\u90e8\u306f<strong>\u53ef\u52d5\u8155<\/strong>\uff0c<strong>\u5909\u63db\u30c9\u30e1\u30a4\u30f3<\/strong>\uff0c<strong>ATP \u7d50\u5408\u90e8\u4f4d<\/strong>\uff0c<strong>\u30a2\u30af\u30c1\u30f3\u7d50\u5408\u90e8\u4f4d<\/strong>\u304b\u3089\u306a\u308b\uff0e\u5909\u63db\u30c9\u30e1\u30a4\u30f3\u306f ATP \u52a0\u6c34\u5206\u89e3\u3092\u69cb\u9020\u5909\u5316\u306b\u5909\u63db\u3059\u308b\u6a5f\u69cb\u3067 ATP \u306e\u672b\u7aef\u30ea\u30f3\u9178\u57fa\u306e\u6709\u7121\u306b\u5fdc\u3058\u3066\u6bd4\u8f03\u7684\u5c0f\u898f\u6a21\u306e\u69cb\u9020\u5909\u5316\u304c\u5897\u5e45\u3055\u308c\uff0c\u5225\u9818\u57df\u306e\u56de\u8ee2\u904b\u52d5\u3092\u8d77\u3053\u3059\uff0e\u30df\u30aa\u30b7\u30f3\u306f\u53ef\u52d5\u8155\u306e\u9996\u632f\u308a\u306b\u3088\u3063\u3066\u30a2\u30af\u30c1\u30f3\u306b\u6cbf\u3063\u3066\u4e00\u6b69\u9032\u3080\uff0e\u30df\u30aa\u30b7\u30f3\u306e\u69cb\u9020\u5909\u5316\u306f\u30a2\u30af\u30c1\u30f3\u7d50\u5408\u90e8\u4f4d\u306e\u7d50\u5408\u89aa\u548c\u6027\u3092\u5909\u5316\u3055\u305b\uff0c\u30df\u30aa\u30b7\u30f3\u982d\u90e8\u306f\u30a2\u30af\u30c1\u30f3\u304b\u3089\u96e2\u308c\u3066\u9055\u3046\u7b87\u6240\u306b\u7d50\u5408\u3059\u308b\uff0e\u3053\u306e\u7d50\u5408\u304c\u5171\u6709\u7d50\u5408\u306a\u306e\u304b\u975e\u5171\u6709\u7d50\u5408\u306a\u306e\u304b\u306f\u5206\u304b\u3063\u3066\u3044\u306a\u3044\uff0e<\/p>\n<p>\u3000\u30df\u30aa\u30b7\u30f3\u306f\u591a\u6570\u306e\u30e2\u30fc\u30bf\u30fc\u982d\u90e8\u304c\u540c\u3058\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306b\u4f5c\u7528\u3059\u308b\u914d\u7f6e\u3092\u53d6\u308a\uff0c1 \u56de\u306e\u30b5\u30a4\u30af\u30eb\u3067\u30e2\u30fc\u30bf\u30fc\u86cb\u767d\u306f 5 nm \u79fb\u52d5\u3059\u308b\uff0e\u30a2\u30af\u30c1\u30f3\u3068\u30df\u30aa\u30b7\u30f3\u306e\u7d50\u5408\u3068\u89e3\u96e2\u306f 1 \u79d2\u9593\u306b\u7d04 5 \u56de\u8d77\u3053\u308a\uff0c\u6ed1\u8d70\u901f\u5ea6\u306f\u6bce\u79d2 15 \u00b5m \u306b\u306a\u308b\uff0e\u4e00\u3064\u306e\u30b5\u30eb\u30b3\u30e1\u30a2\u304c 1 \u30b5\u30a4\u30af\u30eb\u3067\u77ed\u7e2e\u3059\u308b\u9577\u3055\u306f\u50c5\u304b\u3060\u304c\uff0c\u30b5\u30eb\u30b3\u30e1\u30a2\u306f\u76f4\u5217\u306b\u914d\u7f6e\u3057\u3066\u304a\u308a\uff0c\u7b4b\u7d30\u80de\u5168\u4f53\uff0c\u7b4b\u8089\u5168\u4f53\u304c\u4e00\u6589\u306b\u540c\u671f\u3057\u3066\u53ce\u7e2e\u3059\u308b\u3068\u5927\u304d\u306a\u529b\u3092\u767a\u751f\u3059\u308b\uff0e<\/p>\n<p><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/N4cjSW6J4cQ\" frameborder=\"0\" allowfullscreen><\/iframe>\u00a9<em>Essential Cell Biology<\/em><\/p>\n<h3>\u53ce\u7e2e\u306e\u958b\u59cb<\/h3>\n<p>\u3000T \u7ba1\u306e\u819c\u306b\u3042\u308b\u96fb\u4f4d\u4f9d\u5b58\u6027 Ca<sup>2+<\/sup> \u30c1\u30e3\u30cd\u30eb\u304c\u6d3b\u52d5\u96fb\u4f4d\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3059\u308b\u3068\uff0c\u7b4b\u5c0f\u80de\u4f53\u306e Ca<sup>2+<\/sup> \u653e\u51fa\u30c1\u30e3\u30cd\u30eb\u304c\u958b\u304d\uff0c\u7d30\u80de\u8cea\u306b\u5927\u91cf\u306e Ca<sup>2+<\/sup> \u304c\u6d41\u5165\u3057\u3066\u7b4b\u539f\u7dda\u7dad\u306e\u53ce\u7e2e\u304c\u59cb\u307e\u308b\uff0e<\/p>\n<h3>\u30c8\u30ed\u30dd\u30df\u30aa\u30b7\u30f3\uff0c\u30c8\u30ed\u30dd\u30cb\u30f3\u8907\u5408\u4f53\u304a\u3088\u3073 Ca<sup>2+<\/sup><\/h3>\n<p>\u3000\u9759\u6b62\u72b6\u614b\u306e\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306b\u306f<strong>\u30c8\u30ed\u30dd\u30df\u30aa\u30b7\u30f3<\/strong>\u304c\u5dfb\u304d\u3064\u3044\u3066\u304a\u308a\uff0c\u30a2\u30af\u30c1\u30f3\u306e\u30df\u30aa\u30b7\u30f3\u7d50\u5408\u90e8\u4f4d\u3092\u585e\u3044\u3067\u3044\u308b\uff0e\u30c8\u30ed\u30dd\u30df\u30aa\u30b7\u30f3\u306b\u306f<strong>\u30c8\u30ed\u30dd\u30cb\u30f3\u8907\u5408\u4f53<\/strong>\u304c\u7d50\u5408\u3057\u3066\u304a\u308a\uff0cCa<sup>2+<\/sup> \u304c\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u30c8\u30ed\u30dd\u30df\u30aa\u30b7\u30f3\u306e\u4f4d\u7f6e\u304c\u305a\u308c\uff0c\u30a2\u30af\u30c1\u30f3\u3068\u30df\u30aa\u30b7\u30f3\u304c\u7d50\u5408\u51fa\u6765\u308b\u3088\u3046\u306b\u306a\u308b\uff0e<\/p>\n<h3>\u53ce\u7e2e\u306e\u7d42\u4e86<\/h3>\n<p>\u3000Ca<sup>2+<\/sup> \u6fc3\u5ea6\u4e0a\u6607\u306f\u4e00\u6642\u7684\u3067\uff0cCa<sup>2+<\/sup> \u306f\u7b4b\u5c0f\u80de\u4f53\u819c\u306b\u3042\u308b\u591a\u6570\u306e ATP \u4f9d\u5b58\u6027 Ca<sup>2+<\/sup> \u30dd\u30f3\u30d7\u306e\u50cd\u304d\u306b\u3088\u308a\u8fc5\u901f\u306b\u7b4b\u5c0f\u80de\u4f53\u5185\u3078\u623b\u3055\u308c\u308b\uff0eCa<sup>2+<\/sup> \u6fc3\u5ea6\u304c\u9759\u6b62\u72b6\u614b\u306b\u623b\u308b\u3068\u30c8\u30ed\u30dd\u30cb\u30f3\u3068\u30c8\u30ed\u30dd\u30df\u30aa\u30b7\u30f3\u304c\u5143\u306e\u4f4d\u7f6e\u306b\u623b\u308a\uff0c\u53ce\u7e2e\u306f\u7d42\u4e86\u3059\u308b\uff0e<\/p>\n<p><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/IU35U9AbmsM\" frameborder=\"0\" allowfullscreen><\/iframe>\u00a9<em>Essential Cell Biology<\/em><\/p>\n<h3>\u7b4b\u53ce\u7e2e\u306b\u304a\u3051\u308b ATP \u6d88\u8cbb<\/h3>\n<p>\u3000\u7b4b\u53ce\u7e2e\u306b\u304a\u3044\u3066\u306f2\u3064\u306e\u904e\u7a0b\u3067 ATP \u3092\u5927\u91cf\u306b\u6d88\u8cbb\u3059\u308b\uff0e\u4e00\u3064\u306f\u30df\u30aa\u30b7\u30f3\u30e2\u30fc\u30bf\u30fc\u30c9\u30e1\u30a4\u30f3\u306e ATP \u30a2\u30fc\u30bc\u306e\u99c6\u52d5\u3059\u308b\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306e\u6ed1\u8d70\u3067\u3042\u308a\uff0c\u3082\u3046\u4e00\u3064\u306f\u7b4b\u5c0f\u80de\u4f53\u306e Ca<sup>2+<\/sup> \u30dd\u30f3\u30d7\u306b\u3088\u308b Ca<sup>2+<\/sup> \u306e\u6c72\u307f\u4e0a\u3052\u3067\u3042\u308b\uff0e<\/p>\n<h3>\u30bf\u30a4\u30c1\u30f3<\/h3>\n<h4>Winding filament \u4eee\u8aac<\/h4>\n<p>\u30002012 \u5e74\u3054\u308d\u307e\u3067\u306f\u30bf\u30a4\u30c1\u30f3\u5206\u5b50\u306e <a href=\"https:\/\/www.muscle-hypertrophy.com\/?p=3326\" rel=\"noopener\" target=\"_blank\">winding filament \u4eee\u8aac<\/a>\u304c\u652f\u6301\u3055\u308c\u3066\u3044\u305f\uff0e\u30a2\u30af\u30c6\u30a3\u30d6\u30b9\u30c8\u30ec\u30c3\u30c1\uff08\u30a8\u30ad\u30bb\u30f3\u30c8\u30ea\u30c3\u30af\u53ce\u7e2e\uff0c\u4f38\u5f35\u6027\u53ce\u7e2e\uff09\u3067\u306f\u30a2\u30af\u30c6\u30a3\u30d6\u53ce\u7e2e\uff08\u30b3\u30f3\u30bb\u30f3\u30c8\u30ea\u30c3\u30af\u53ce\u7e2e\uff0c\u77ed\u7e2e\u6027\u53ce\u7e2e\uff09\u3088\u308a\u3082\u5f37\u3044\u529b\u304c\u51fa\u308b\u3053\u3068\u306f\u7d4c\u9a13\u7684\u306b\u77e5\u3089\u308c\u3066\u3044\u305f\u304c\uff0c\u305d\u306e\u6a5f\u5e8f\u3068\u3057\u3066\u6709\u529b\u306a\u8aac\u304c\u3053\u308c\u3067\u3042\u3063\u305f\uff0e<\/p>\n<p>\u3000\u3064\u307e\u308a\uff0c\u77ed\u7e2e\u6027\u53ce\u7e2e\u306e\u969b\u306b\u30bf\u30a4\u30c1\u30f3\u306e PEVK \u30c9\u30e1\u30a4\u30f3\u304c\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306e\u5468\u56f2\u306b\u5dfb\u304d\u3064\u304d\uff0c\u5f3e\u6027\u30dd\u30c6\u30f3\u30b7\u30e3\u30eb\u30a8\u30ca\u30b8\u30fc\u3092\u5206\u5b50\u5185\u306b\u84c4\u7a4d\u3059\u308b\uff0e\u4f38\u5f35\u6027\u53ce\u7e2e\u306e\u969b\u306b\u306f\u305d\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u89e3\u653e\u3057\u3064\u3064\u4f38\u9577\u3059\u308b\u305f\u3081\u306b\uff0c\u77ed\u7e2e\u6027\u53ce\u7e2e\u3088\u308a\u3082\u5f37\u3044\u529b\u3092\u767a\u63ee\u3059\u308b\u3068\u3044\u3046\u3082\u306e\u3067\u3042\u308b\uff0e<\/p>\n<figure id=\"attachment_3336\" aria-describedby=\"caption-attachment-3336\" style=\"width: 525px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/07\/F2.large_.jpg\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/07\/F2.large_-1024x717.jpg\" alt=\"\" width=\"525\" height=\"368\" class=\"size-large wp-image-3336\" srcset=\"https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/07\/F2.large_-1024x717.jpg 1024w, https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/07\/F2.large_-300x210.jpg 300w, https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/07\/F2.large_-768x538.jpg 768w, https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/07\/F2.large_.jpg 1280w\" sizes=\"auto, (max-width: 525px) 100vw, 525px\" \/><\/a><figcaption id=\"caption-attachment-3336\" class=\"wp-caption-text\"><strong>Figure 2. Winding filament \u4eee\u8aac\u306e\u6982\u7565\u56f3\uff0e<\/strong>(a,b) Ca<sup>2+<\/sup> \u4f9d\u5b58\u6027\u306e N2A \u306e\u7d30\u3044\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u3078\u306e\u7d50\u5408\u306f\u9577\u3055\u3068\u5f35\u529b\u306e\u95a2\u4fc2\u306b\u5bc4\u4e0e\u3059\u308b\uff0e\u4eee\u306b N2A (\u8d64) \u304c\u975e\u9078\u629e\u7684\u306b\u7d30\u3044\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\uff08\u9752\uff09\u306b\u5bfe\u3057\u3066 Ca<sup>2+<\/sup> \u5b58\u5728\u4e0b\u306b\u7d50\u5408\u3057\u305f\u3089\uff0c\u305d\u3057\u3066\u4eee\u306b\u305d\u306e\u7d50\u5408\u90e8\u4f4d\u304c Ca<sup>2+<\/sup> \u6d41\u5165\u6642\u306b\u30b5\u30eb\u30b3\u30e1\u30a2\u9577\u306b\u4f9d\u5b58\u6027\u3067\u3042\u308c\u3070\uff0c\u30a6\u30b5\u30ae\u306e\u5927\u8170\u7b4b\u306b\u304a\u3044\u3066 (a) 2.4 \u00b5m \u3068 (b) 2.6 \u00b5m \u306e\u9593\u3067\u30b5\u30eb\u30b3\u30e1\u30a2\u9577\u3067\u306e\u6d3b\u52d5\u6027\u306e\u529b\u306b\u306f\u30d7\u30e9\u30c8\u30fc\u304c\u793a\u5506\u3055\u308c\u308b\uff0e(c,d) \u67b6\u6a4b\u306e\u30b5\u30a4\u30af\u30eb\u306f\u30bf\u30a4\u30c1\u30f3\u306e\u306d\u3058\u308c\u308b\u7d50\u679c\u3068\u306a\u308b\uff0e(c) \u67b6\u6a4b\u306e\u30b5\u30a4\u30af\u30eb\u306f PEVK \u3092\u7d30\u3044\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u306b\u5dfb\u304d\u3064\u3051\u308b\uff08\u77e2\u5370\u306f\u56de\u8ee2\u65b9\u5411\u3092\u793a\u3059\uff09\uff0e\u3053\u306e\u30e2\u30c7\u30eb\u3067\u306f\uff0c\u5dfb\u304d\u3064\u3051\u89d2\u5ea6\u306f\u30b5\u30eb\u30b3\u30e1\u30a2\u306e\u5e7e\u4f55\u5b66\u7684\u5f62\u72b6\u306b\u306e\u307f\u4f9d\u5b58\u3059\u308b\uff0e(d) \u6d3b\u52d5\u4e2d\u306e\u30b5\u30eb\u30b3\u30e1\u30a2\u306e\u4f38\u9577\u306f PEVK \u30bb\u30b0\u30e1\u30f3\u30c8\u3092\u4f38\u5c55\u3057\uff0c\u30a2\u30af\u30c6\u30a3\u30d6\u306a\u529b\u3092\u5897\u5f37\u3059\u308b\uff0e<\/figcaption><\/figure>\n<p>\u3000\u3053\u306e\u4eee\u8aac\u306b\u306f\u4e00\u5b9a\u306e\u8aac\u5f97\u529b\u304c\u3042\u3063\u305f\u3082\u306e\u306e, 2018 \u5e74\u6642\u70b9\u3067\u306f\u3082\u306f\u3084\u5426\u5b9a\u3055\u308c\u3064\u3064\u3042\u308b\uff0e\u3068\u3044\u3046\u306e\u3082\uff0c\u6700\u65b0\u306e\u89b3\u6e2c\u6280\u8853\u306b\u3088\u308a\u3053\u306e\u4eee\u8aac\u3092\u5426\u5b9a\u3059\u308b\u7d50\u679c\u304c\u51fa\u3066\u304d\u305f\u305f\u3081\u3067\u3042\u308b\uff0e<\/p>\n<h4>Titin folding \u4eee\u8aac<\/h4>\n<p>\u3000\u539f\u5b50\u9593\u529b\u9855\u5fae\u93e1\u3068\u3044\u3046\u6a5f\u5668\u304c\u3042\u308b\uff0e\u3053\u308c\u306f\u89e3\u50cf\u5ea6\u304c\u30ca\u30ce\u30e1\u30fc\u30c8\u30eb\u3068\u3044\u3046\u9014\u65b9\u3082\u306a\u3044\u8d85\u9ad8\u89e3\u50cf\u5ea6\u306e\u9855\u5fae\u93e1\u3067\uff0c\u73fe\u5728\u3067\u306f\u9759\u6b62\u753b\u306a\u3089\u539f\u5b50\u30ec\u30d9\u30eb\u306e\u5206\u89e3\u80fd\u304c\u3042\u308b\uff0e\u5192\u982d\u306b\u793a\u3057\u305f\u52d5\u753b\u306f\u5b89\u85e4\u654f\u592b\u3089\u306b\u3088\u308b\u3082\u306e\u3067\uff0c\u9ad8\u901f\u539f\u5b50\u9593\u529b\u9855\u5fae\u93e1\u306b\u3088\u308a V \u578b\u30df\u30aa\u30b7\u30f3\u5206\u5b50\u304c\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u4e0a\u3092\u300c\u6b69\u304f\u300d\u69d8\u5b50\u3092\u76f4\u63a5\u64ae\u5f71\u3057\u305f\u3082\u306e\u3067\u3042\u308b\uff0e\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u30b0\u30e9\u30d5\u30a3\u30c3\u30af\u30b9\u3067\u306f\u306a\u3044\uff0c\u672c\u7269\u306e\u5206\u5b50\u306e\u6319\u52d5\u3067\u3042\u308b\uff0e<\/p>\n<p>\u3000\u3053\u306e\u539f\u5b50\u9593\u529b\u9855\u5fae\u93e1\u306b\u3088\u308b\u89b3\u6e2c\u306b\u3088\u308a\uff0c\u7b4b\u53ce\u7e2e\u306e\u969b\u306e\u8a73\u7d30\u306a\u30bf\u30a4\u30c1\u30f3\u306e\u6319\u52d5\u304c\u5206\u304b\u3063\u3066\u304d\u305f\uff0e<\/p>\n<p>\u3000\u500b\u3005\u306e\u30bf\u30a4\u30c1\u30f3\u5206\u5b50\u3092\u7e70\u308a\u8fd4\u3057\u5f15\u304d\u4f38\u3070\u3057\uff0c\u52a0\u3048\u305f\u529b\u3092\u4f38\u9577\u306e\u95a2\u6570\u3068\u3057\u3066\u8a18\u9332\u3057\u305f\u3068\u3053\u308d, 25-28 nm \u3054\u3068\u306b\u5468\u671f\u6027\u306e\u3042\u308b\u92f8\u6b6f\u72b6\u30d1\u30bf\u30fc\u30f3\u304c\u73fe\u308c\u305f\uff0e\u500b\u3005\u306e\u9818\u57df\u3092\u5c55\u958b\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u306a\u529b\u306f, 150-300 \u30d4\u30b3\u30cb\u30e5\u30fc\u30c8\u30f3\u306e\u7bc4\u56f2\u3067\u3042\u308a\uff0c\u5f15\u3063\u5f35\u308a\u901f\u5ea6\u306b\u4f9d\u5b58\u3057\u305f\uff0e\u5f1b\u7de9\u3055\u305b\u308b\u3068 Ig \u30c9\u30e1\u30a4\u30f3\u306e\u518d\u6298\u308a\u305f\u305f\u307f\u304c\u89b3\u6e2c\u3055\u308c\u305f (<a href=\"https:\/\/www.semanticscholar.org\/paper\/Reversible-unfolding-of-individual-titin-domains-by-Rief-Gautel\/082427a4590025be1bea082249a81ad67587f6d4\" rel=\"noopener\" target=\"_blank\">Matthias Rief, Mathias Gautel, 1997<\/a>). <\/p>\n<figure id=\"attachment_3520\" aria-describedby=\"caption-attachment-3520\" style=\"width: 525px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/08\/ReversibleUnfoldingTitin-Figure2.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/08\/ReversibleUnfoldingTitin-Figure2-1024x484.png\" alt=\"\" width=\"525\" height=\"248\" class=\"size-large wp-image-3520\" srcset=\"https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/08\/ReversibleUnfoldingTitin-Figure2-1024x484.png 1024w, https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/08\/ReversibleUnfoldingTitin-Figure2-300x142.png 300w, https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/08\/ReversibleUnfoldingTitin-Figure2-768x363.png 768w, https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/08\/ReversibleUnfoldingTitin-Figure2.png 1446w\" sizes=\"auto, (max-width: 525px) 100vw, 525px\" \/><\/a><figcaption id=\"caption-attachment-3520\" class=\"wp-caption-text\"><strong>Fig. 2.<\/strong> \u3088\u304f\u5b9a\u7fa9\u3055\u308c\u305f\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u30bf\u30a4\u30c1\u30f3\u30bb\u30b0\u30e1\u30f3\u30c8\u306f force extension curves \u3092\u751f\u6210\u3057\uff0c\u305d\u308c\u306f\u500b\u3005\u306e Ig \u30c9\u30e1\u30a4\u30f3\u306e\u30a2\u30f3\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u3068\u4e00\u81f4\u3057\u3066\u3044\u308b\uff0e\u6211\u3005\u306f\u4e8c\u3064\u306e\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u30bf\u30a4\u30c1\u30f3\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u3092\u958b\u767a\u3057\u305f\uff0e\u3064\u307e\u308a, 8 \u500b\u306e Ig \u30c9\u30e1\u30a4\u30f3 (Ig8, I27-I34 \u306b\u307e\u305f\u304c\u308b\uff0e\u633f\u5165\u56f3 1 \u53c2\u7167) \u304a\u3088\u3073 4 \u500b\u306e Ig \u30c9\u30e1\u30a4\u30f3 (Ig4, I27-I30 \u306b\u307e\u305f\u304c\u308b) \u3067\u3042\u308b\uff0e\u305d\u306e\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u30bf\u30a4\u30c1\u30f3\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u306f COOH \u672b\u7aef\u306b\u4e8c\u3064\u306e\u30b7\u30b9\u30c6\u30a4\u30f3\u30a2\u30df\u30ce\u9178\u3092\u4ed8\u52a0\u3057\u3066\u69cb\u7bc9\u3057\u3066\u3042\u308a\uff0c\u91d1\u8868\u9762\u306b\u5171\u6709\u7d50\u5408\u30a2\u30f3\u30ab\u30fc\u3092\u65bd\u3057\u3066\u3042\u308b. AFM \u63a2\u91dd\u306f\u63a5\u89e6\u3057\u3066\u4ed6\u306e\u672b\u7aef\u3092\u30d4\u30c3\u30af\u30a2\u30c3\u30d7\u3059\u308b. <strong>(A)<\/strong> \u4f38\u5c55\u4e2d\u306e Ig8 \u30c9\u30e1\u30a4\u30f3\u306f force extension curves \u3092\u751f\u6210\u3057\uff0c\u305d\u308c\u306b\u306f\u516b\u3064\u306e\u7b49\u9593\u9694\u306e\u529b\u306e\u4e0a\u6607\u30d4\u30fc\u30af\u3092\u4f34\u3044\uff0c\u529b\u306e\u7bc4\u56f2\u306f 150 \u304b\u3089\u6700\u5927 300 pN \u3067\u3042\u3063\u305f\uff0e\u30d4\u30fc\u30af\u306e\u6700\u5927\u6570\u3092\u793a\u3059\u66f2\u7dda\u306e\u307f\u793a\u3059. <strong>(B)<\/strong> Ig8 \u86cb\u767d\u8cea\u304b\u3089\u5f97\u3089\u308c\u305f force extension curves \u3092\u91cd\u306d\u5408\u308f\u305b, 100 pN \u3067\u6e2c\u5b9a\u3057\u305f 25 nm \u306e\u529b\u306e\u30d4\u30fc\u30af\u9593\u306e\u9593\u9694\u3092\u660e\u3089\u304b\u306b\u3057\u305f\uff0e\u5404\u8a18\u9332\u306e\u6700\u5f8c\u306e\u30d4\u30fc\u30af\u306f\u901a\u5e38\uff0c\u5148\u884c\u3059\u308b\u914d\u5217\u306e\u30d4\u30fc\u30af\u3088\u308a\u3082\u304b\u306a\u308a\u9ad8\u304f, Ig \u30c9\u30e1\u30a4\u30f3\u306e\u89e3\u660e\u3092\u53cd\u6620\u3057\u3066\u3044\u306a\u3044\u304c\uff0c\u5148\u7aef\u306b\u5438\u7740\u3057\u3066\u3042\u308b\u69cb\u9020\u7269\u304c\u5265\u96e2\u3057\u305f\u3053\u3068\u306b\u8d77\u56e0\u3057\u3066\u3044\u308b.  <strong>(C)<\/strong> \u3088\u308a\u77ed\u3044\u30bf\u30a4\u30c1\u30f3\u30bb\u30b0\u30e1\u30f3\u30c8 Ig4 \u304c\u4f38\u5c55\u3059\u308b\u969b\u306b\u751f\u6210\u3057\u305f force extension curve \u306b\u306f\u6700\u5927 4 \u3064\u306e\u529b\u306e\u92f8\u6b6f\u72b6\u30d1\u30bf\u30fc\u30f3\u3092\u6709\u3057\u3066\u3044\u305f. <strong>(D)<\/strong> Ig4 \u3067\u5f97\u3089\u308c\u305f force extension curve \u3092\u91cd\u306d\u5408\u308f\u305b\u308b\u3068 Ig8 \u3067\u5f97\u3089\u308c\u305f\u306e\u3068\u540c\u69d8\u306e\u529b\u306e\u30d4\u30fc\u30af\u3092\u793a\u3057\u3066\u304a\u308a\uff0c\u540c\u69d8\u306b 25 nm \u306e\u9593\u9694\u3067\u3042\u3063\u305f. <strong>(E)<\/strong> \u4e09\u3064\u306e\u5168\u3066\u306e\u30bf\u30a4\u30c1\u30f3\u306e\u5f62\u614b\u304b\u3089\u5f97\u3089\u308c\u305f force extension curve. \u4e0a\u304b\u3089\u9806\u306b Ig4, Ig8, \u91ce\u751f\u578b. <strong>(F)<\/strong> \u6211\u3005\u306e\u89b3\u5bdf\u306f\u500b\u3005\u306e Ig \u30c9\u30e1\u30a4\u30f3\u304c\u9023\u7d9a\u306b\u30a2\u30f3\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u3057\u3066\u3044\u308b\u306e\u3060\u308d\u3046\u3068\u6211\u3005\u306f\u89e3\u91c8\u3057\u3066\u3044\u308b\uff0e\u3053\u306e\u56f3\u306f\u53ef\u80fd\u6027\u306e\u3042\u308b\u4e00\u9023\u306e\u30a4\u30d9\u30f3\u30c8\u3092\u793a\u3057\u3066\u3044\u308b. (1) \u91d1\u8868\u9762\u306b\u5171\u6709\u7d50\u5408\u3057\u305f Ig4 \u306f, AFM \u30c1\u30c3\u30d7\u306e\u5438\u7740\u306b\u3088\u308a\u6355\u6349\u3055\u308c\u308b. AFM \u5148\u7aef\u304c\u5f15\u3063\u8fbc\u3080\u3068\u30c9\u30e1\u30a4\u30f3\u306f\u30a2\u30f3\u30d5\u30a9\u30fc\u30eb\u30c9\u3059\u308b. \u92f8\u6b6f\u72b6\u30d1\u30bf\u30fc\u30f3\u306f\uff0c\u6a5f\u68b0\u7684\u306b\u76f4\u5217\u3067\u3042\u308b Ig \u30c9\u30e1\u30a4\u30f3\u306e\u9023\u7d9a\u3059\u308b\u30a2\u30f3\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u304b\u3089\u751f\u3058\u308b\uff0e\u30c9\u30e1\u30a4\u30f3\u304c\u30a2\u30f3\u30d5\u30a9\u30fc\u30eb\u30c9\u3059\u308b\u524d\u306b\uff0c\u4f38\u9577\u3055\u308c\u305f\u30dd\u30ea\u30da\u30d7\u30c1\u30c9\u306f 150 &#8211; 300 pN \u306e\u4fdd\u6301\u529b\u306b\u9054\u3059\u308b\u307e\u3067\u5f15\u304d\u4f38\u3070\u3055\u308c\uff0c\u3057\u304b\u308b\u5f8c\u30a2\u30f3\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u304c\u9ad8\u3044\u78ba\u7387\u3067\u767a\u751f\u3059\u308b. (2) Ig\u30c9\u30e1\u30a4\u30f3\u306e\u30a2\u30f3\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u306f\u4fdd\u6301\u529b\u3092\u7a81\u7136\u4f4e\u4e0b\u3055\u305b\u308b\uff0e\u3068\u3044\u3046\u306e\u306f\uff0c\u4f38\u9577\u3057\u305f\u30dd\u30ea\u30da\u30d7\u30c1\u30c9\u306e\u9577\u3055\u304c 25 nm \u5897\u52a0\u3059\u308b\u305f\u3081\u3067\u3042\u308b. (3) \u5f15\u304d\u7d9a\u304d AFM \u30c1\u30c3\u30d7\u3092\u5f15\u304d\u623b\u3059\u3068\uff0c\u6b21\u306e Ig \u30c9\u30e1\u30a4\u30f3\u304c\u30a2\u30f3\u30d5\u30a9\u30fc\u30eb\u30c9\u3059\u308b\u529b\u306b\u9054\u3059\u308b\u307e\u3067\uff0c\u4f38\u9577\u3057\u305f\u30dd\u30ea\u30da\u30d7\u30c1\u30c9\u304c\u5f15\u304d\u4f38\u3070\u3055\u308c\u308b\uff0e\u3042\u308b\u30c9\u30e1\u30a4\u30f3\u304c\u30a2\u30f3\u30d5\u30a9\u30fc\u30eb\u30c9\u3059\u308b\u3068\uff0c\u305d\u306e AFM \u5148\u7aef\u306f 2-4 nm \u3060\u3051\u5f3e\u304b\u308c\u3066\u9759\u6b62\u4f4d\u7f6e\u306b\u623b\u308b\uff0e\u3053\u308c\u306f force curve \u306b\u76f2\u76ee\u306e\u7a93\u3092\u6b8b\u3059\u3053\u3068\u306b\u306a\u308a\uff0c\u305d\u3053\u3067\u306f\u30a2\u30f3\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u306e\u904e\u7a0b\u306e\u69cb\u9020\u306f\u89b3\u5bdf\u3055\u308c\u306a\u3044\uff0e<\/figcaption><\/figure>\n<p>\u3000\u3053\u306e\u5468\u671f\u6027\u306e\u3042\u308b\u92f8\u6b6f\u72b6\u30d1\u30bf\u30fc\u30f3\u306f winding filament \u4eee\u8aac\u3067\u306f\u8aac\u660e\u304c\u3064\u304b\u306a\u3044\uff0e\u4e00\u672c\u306e\u9577\u3044\u5206\u5b50\u304c\u7cf8\u5dfb\u304d\u306e\u3088\u3046\u306b\u30a2\u30af\u30c1\u30f3\u306b\u5dfb\u304d\u4ed8\u3044\u3066\u3044\u304f\u30e2\u30c7\u30eb\u3067\u306f\u92f8\u6b6f\u72b6\u306e\u30d1\u30bf\u30fc\u30f3\u306f\u51fa\u73fe\u305b\u305a\uff0c\u6ed1\u3089\u304b\u306a\u7dda\u5f62\u6027\u3092\u793a\u3059\u306f\u305a\u3060\u304b\u3089\u3067\u3042\u308b\uff0e\u4e0a\u306e\u56f3\u306e E \u304c\u89b3\u6e2c\u3055\u308c\u305f\u7d50\u679c\u3067\u3042\u308a\uff0c\u305d\u306e\u7d50\u679c F \u306e\u30e2\u30c7\u30eb\u304c\u8003\u3048\u3089\u308c\u305f\uff0e\u3053\u308c\u304c titin folding \u4eee\u8aac\u3067\u3042\u308b\uff0e<\/p>\n<p>\u3000\u30bf\u30a4\u30c1\u30f3\u3092\u5f15\u304d\u4f38\u3070\u3059\u529b\u304c\u52a0\u308f\u308b\u3068, 150-300 \u30d4\u30b3\u30cb\u30e5\u30fc\u30c8\u30f3\u306b\u9054\u3059\u308b\u3054\u3068\u306b\u4e00\u3064\u306e\u6298\u308a\u305f\u305f\u307e\u308c\u305f\u9818\u57df\uff08Ig \u30c9\u30e1\u30a4\u30f3\uff09\u304c\u5f15\u304d\u4f38\u3070\u3055\u308c\u308b\uff08\u30a2\u30f3\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\uff09\uff0e\u5f15\u304d\u4f38\u3070\u3055\u308c\u308b\u3068\u6025\u6fc0\u306b\u53ce\u7e2e\u529b\u3092\u5931\u3046\u305f\u3081\u306b\u30b0\u30e9\u30d5\u304c\u843d\u3061\u8fbc\u3080\uff0e\u3053\u306e 1 \u500b\u3042\u305f\u308a\u306e\u9577\u3055\u304c 25-28 nm \u3067\u3042\u308b\uff0e\u6b21\u306e\u6298\u308a\u305f\u305f\u307f\u9818\u57df\u306b\u727d\u5f15\u529b\u304c\u96c6\u4e2d\u3057, 150-300 \u30d4\u30b3\u30cb\u30e5\u30fc\u30c8\u30f3\u306b\u9054\u3059\u308b\u3068\u305d\u308c\u304c\u5f15\u304d\u4f38\u3070\u3055\u308c\u308b&#8230;\u305d\u306e\u7e70\u308a\u8fd4\u3057\u3067\u3042\u308b\uff0e<\/p>\n<p>\u3000\u3053\u306e\u6298\u308a\u305f\u305f\u307f\u9818\u57df\u306e\u5f15\u304d\u4f38\u3070\u3057\u306f\u30b5\u30eb\u30b3\u30e1\u30a2\u304c\u5f15\u304d\u4f38\u3070\u3055\u308c\u308b\u6642\u306b\u8d77\u304d\u3066\u304a\u308a\uff0c\u30bf\u30a4\u30c1\u30f3 Ig \u30c9\u30e1\u30a4\u30f3\u306e\u6298\u308a\u305f\u305f\u307f\u9818\u57df\u304c\u5f15\u304d\u4f38\u3070\u3055\u308c\u3066\u5f3e\u6027\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u84c4\u7a4d\u3057\u3066\u3044\u308b\uff0e\u30bf\u30a4\u30c1\u30f3 Ig \u30c9\u30e1\u30a4\u30f3\u306f\u6298\u308a\u305f\u305f\u307e\u308c\u305f\u72b6\u614b\u304c\u30a8\u30cd\u30eb\u30ae\u30fc\u6e96\u4f4d\u3068\u3057\u3066\u5b89\u5b9a\u3057\u305f\u72b6\u614b\u3067\u3042\u308b\u305f\u3081\uff0c\u5916\u529b\u304c\u304b\u304b\u3089\u306a\u304f\u306a\u308b\u3068\u5185\u90e8\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u6368\u3066\u3066\u6298\u308a\u305f\u305f\u3093\u3060\u72b6\u614b\u306b\u623b\u308d\u3046\u3068\u3059\u308b\uff0e\u305d\u3057\u3066\u30b5\u30eb\u30b3\u30e1\u30a2\u306b\u304b\u304b\u308b\u727d\u5f15\u529b\u304c\u6e1b\u5c11\u3057\u305f\u969b\u306b\u5f15\u304d\u4f38\u3070\u3055\u308c\u305f\u9818\u57df\u304c\u518d\u5ea6\u6298\u308a\u305f\u305f\u307e\u308c\u3066\uff08\u518d\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\uff09\uff0c\u84c4\u7a4d\u3055\u308c\u305f\u5f3e\u6027\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u89e3\u653e\u3059\u308b\u305f\u3081\uff0c\u30df\u30aa\u30b7\u30f3\u5358\u72ec\u3088\u308a\u3082\u5f37\u3044\u529b\u3092\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u308b\uff0e<\/p>\n<p>\u3000\u86cb\u767d\u8cea\u306e\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u53ce\u7e2e\u3068\u3044\u3046\u65b0\u3057\u3044\u767a\u898b\u306f\uff0c\u6b21\u306e\u4e09\u3064\u306e\u8981\u7d20\u306b\u3088\u308b\uff0e\u3059\u306a\u308f\u3061\uff0c\u9759\u96fb\u76f8\u4e92\u4f5c\u7528\uff0c\u6c34\u7d20\u7d50\u5408\u304a\u3088\u3073\u758e\u6c34\u76f8\u4e92\u4f5c\u7528\u3067\u3042\u308b\uff0e\u4e00\u65e6\u30a2\u30f3\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u304c\u8d77\u304d\u308b\u3068\uff0c\u305d\u306e\u30dd\u30ea\u30da\u30d7\u30c1\u30c9\u306f\u30e9\u30f3\u30c0\u30e0\u30b3\u30a4\u30eb\u3068\u306a\u308b\uff0e\u3053\u308c\u306f\u81ea\u7531\u7d50\u5408\u9396\u30e2\u30c7\u30eb\u306b\u3088\u304f\u9069\u5408\u3059\u308b\u304c\uff0c\u30b4\u30e0\u30d0\u30f3\u30c9\u306e\u3088\u3046\u306a\u7dda\u5f62\u5f3e\u6027\u3068\u306f\u5bfe\u7167\u7684\u306b\uff0c\u30dd\u30ea\u30de\u30fc\u306e\u30a8\u30f3\u30c8\u30ed\u30d4\u30fc\u53cd\u52d5\u306f\u9ad8\u5ea6\u306b\u975e\u7dda\u5f62\u6027\u3067\u3042\u308b. Force clamp \u6cd5\u306b\u3088\u308a\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u306e\u306f\uff0c\u30e2\u30eb\u30c6\u30f3\u30fb\u30b0\u30ed\u30d3\u30e5\u30fc\u30eb\u9077\u79fb\u3078\u306e\u6298\u308a\u305f\u305f\u307f\u3067\u3042\u308a\uff0c\u758e\u6c34\u6027\u6b8b\u57fa\u306e\u86cb\u767d\u8cea\u30b3\u30a2\u3078\u306e\u9694\u96e2\u306b\u3088\u308a\u99c6\u52d5\u3055\u308c\u308b\uff0e\u30a2\u30f3\u30d5\u30a9\u30fc\u30eb\u30c9\u3057\u305f\u86cb\u767d\u8cea\u3092\u727d\u5f15\u3059\u308b\u529b\u3092\u300c\u6025\u505c\u6b62\u300d\u3059\u308b\u3068\uff0c\u305d\u306e\u86cb\u767d\u8cea\u306f\u307e\u305a\u5f3e\u6027\u53ce\u7e2e\u3057\uff0c\u305d\u306e\u5f8c\u3084\u3084\u9045\u308c\u3066\u727d\u5f15\u529b\u306b\u62b5\u6297\u3057\u3066\u6a5f\u68b0\u7684\u4ed5\u4e8b\u3092\u884c\u3044\uff0c\u5b8c\u5168\u306b\u6298\u308a\u305f\u305f\u307e\u308c\u305f\u9577\u3055\u306b\u77ed\u7e2e\u3059\u308b\uff0e\u3053\u306e\u6642\uff0c\u6c34\u7d20\u7d50\u5408\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306e\u518d\u69cb\u7bc9\u304c\u8d77\u304d\u3066\u3044\u308b\uff0e<\/p>\n<figure id=\"attachment_3598\" aria-describedby=\"caption-attachment-3598\" style=\"width: 525px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/08\/TitinFoldingFigure3.jpg\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/08\/TitinFoldingFigure3-756x1024.jpg\" alt=\"\" width=\"525\" height=\"711\" class=\"size-large wp-image-3598\" srcset=\"https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/08\/TitinFoldingFigure3-756x1024.jpg 756w, https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/08\/TitinFoldingFigure3-222x300.jpg 222w, https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/08\/TitinFoldingFigure3-768x1040.jpg 768w, https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/08\/TitinFoldingFigure3.jpg 1084w\" sizes=\"auto, (max-width: 525px) 100vw, 525px\" \/><\/a><figcaption id=\"caption-attachment-3598\" class=\"wp-caption-text\"><strong>Figure 3<\/strong><br \/><strong>\u30bf\u30a4\u30c1\u30f3\u306f\uff0c\u7b4b\u8089\u304c\u30df\u30aa\u30b7\u30f3\u306e\u5931\u901f\u3059\u308b\u529b\u3092\u8d85\u3048\u308b\u8ca0\u8377\u3067\u50cd\u304f\u3053\u3068\u3092\u53ef\u80fd\u306b\u3059\u308b<\/strong><br \/><strong>(A)<\/strong> \u5358\u5206\u5b50\u7814\u7a76\u304b\u3089\u306e\u30df\u30aa\u30b7\u30f3\u30e2\u30fc\u30bf\u30fc\u3068\u30bf\u30a4\u30c1\u30f3 Ig \u30c9\u30e1\u30a4\u30f3\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u8ad6\u306e\u6bd4\u8f03: 8 \u500b\u307e\u3067\u306e\u30df\u30aa\u30b7\u30f3\u982d\u90e8\u304c\u5149\u30c8\u30e9\u30c3\u30d7\u4e2d\u306e\u30a2\u30af\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u3092\u63a8\u9032\u3057\u305f\u5b9f\u9a13\u304b\u3089\u306e\u30c7\u30fc\u30bf\u306f\uff0c\u30df\u30aa\u30b7\u30f3\u304c 6 pN \u306e\u8ca0\u8377\u306b\u5bfe\u3057\u3066\u5931\u901f\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16169988\" rel=\"noopener\" target=\"_blank\">82<\/a>). \u305d\u306e\u30c7\u30fc\u30bf\u306f A.V.Hill \u306e\u516c\u5f0f\uff08\u7dd1\u8272\u306e\u66f2\u7dda\uff09\u306b\u5408\u81f4\u3059\u308b\uff0e\u3042\u308b\u3044\u306f\uff0c\u30bf\u30a4\u30c1\u30f3 Ig \u30c9\u30e1\u30a4\u30f3\u306f 5.7 pN \u307e\u3067\uff08\u9752\u8272\u66f2\u7dda\u306e\u30d4\u30fc\u30af\uff09\u306e\u529b\u3067 46 zJ \u306e\u4ed5\u4e8b\u306e\u6700\u9069\u306a\u4f9b\u7d66\u3092\u9054\u6210\u3059\u308b\uff0e\u3057\u305f\u304c\u3063\u3066, 6-12 pN \uff08\u7070\u8272\u306e\u9670\u5f71\u90e8\u5206\uff09\u306e\u8ca0\u8377\u3067\u306f\uff0c\u30df\u30aa\u30b7\u30f3\u306e\u51fa\u529b\u304c\u30de\u30a4\u30ca\u30b9\u3067\u3042\u308b\u306e\u306b\u5bfe\u3057\u3066\uff0c\u30bf\u30a4\u30c1\u30f3\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u306f\u6709\u7528\u306a\u53ce\u7e2e\u306e\u4ed5\u4e8b\u3092\u767a\u751f\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b. <strong>(B)<\/strong> \u30bf\u30a4\u30c1\u30f3\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u306b\u3088\u3063\u3066\u30df\u30aa\u30b7\u30f3\u30e2\u30fc\u30bf\u30fc\u304c\u524d\u9032\u3059\u308b: (1) \u7b4b\u8089\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u524d\u306b\u30bf\u30a4\u30c1\u30f3\u306f 12 pN \u306e\u53d7\u52d5\u7684\u8ca0\u8377\u5168\u4f53\u3092\u8ca0\u62c5\u3057\uff0c\u305d\u306e\u7d50\u679c, Ig \u30c9\u30e1\u30a4\u30f3\u306e\u30a2\u30f3\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u304c\u8d77\u3053\u308b\uff0e (2) \u30ab\u30eb\u30b7\u30a6\u30e0\u304c\u653e\u51fa\u3055\u308c\u308b\u3068\uff0c\u30a2\u30af\u30c8\u30df\u30aa\u30b7\u30f3\u67b6\u6a4b\u304c\u5f62\u6210\u3055\u308c\u308b\u304c\uff0c\u305d\u306e\u30e2\u30fc\u30bf\u30fc\u306f\u5931\u901f\u3057\u3066\u3044\u308b\u305f\u3081, 6 pN \u306e\u529b\u3057\u304b\u767a\u751f\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\uff0e\u3057\u304b\u3057\uff0c\u30e2\u30fc\u30bf\u30fc\u306b\u3088\u3063\u3066\u767a\u751f\u3057\u305f\u529b\u306f\u30bf\u30a4\u30c1\u30f3\u30c9\u30e1\u30a4\u30f3\u304c\u53d7\u3051\u308b\u8ca0\u8377\u3092 6 pN \u306b\u6e1b\u5c11\u3055\u305b\uff0c\u7d50\u679c\u3068\u3057\u3066 10 nm \u307e\u3067\u306e\u518d\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u30b9\u30c6\u30c3\u30d7\u3092\u3082\u305f\u3089\u3059. (3) \u86cb\u767d\u8cea\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u306e\u30d7\u30ed\u30bb\u30b9\u306f\u30bf\u30a4\u30c1\u30f3\u30d5\u30a3\u30e9\u30e1\u30f3\u30c8\u3092\u77ed\u7e2e\u3057\uff0c\u30df\u30aa\u30b7\u30f3\u30e2\u30fc\u30bf\u30fc\u306e\u8ca0\u62c5\u3092\u8efd\u6e1b\u3057\u3066\u30d1\u30ef\u30fc\u30b9\u30c8\u30ed\u30fc\u30af\u306e\u5b8c\u4e86\u3092\u53ef\u80fd\u306b\u3059\u308b\uff0e\u3053\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304b\u3089\uff0c\u30bf\u30a4\u30c1\u30f3\u306f\u67b6\u6a4b\u5f62\u6210\u306a\u3057\u3067\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u3060\u3051\u3067\u306a\u304f\uff0c\u30d1\u30ef\u30fc\u30b9\u30c8\u30ed\u30fc\u30af\u306e\u5b8c\u4e86\u3082\u307e\u305f\u30bf\u30a4\u30c1\u30f3\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u306b\u4f9d\u5b58\u3059\u308b\u3053\u3068\u3082\u660e\u3089\u304b\u3067\u3042\u308b\uff0e\u5f93\u3063\u3066\uff0c\u30bf\u30a4\u30df\u30f3\u3068\u30df\u30aa\u30b7\u30f3\u306f\u3001\u9ad8\u3044\u8ca0\u8377\u306b\u5bfe\u3057\u3066\u30b5\u30eb\u30b3\u30e1\u30a2\u3092\u77ed\u7e2e\u3059\u308b\u305f\u3081\u306b\u624b\u3092\u643a\u3048\u3066\u50cd\u304f\uff0e<\/figcaption><\/figure>\n<p>\u3000\u3055\u3089\u306b\u7cbe\u5bc6\u306a\u5b9f\u9a13\u304c\u884c\u308f\u308c\uff0c\u30bf\u30a4\u30c1\u30f3 Ig \u30c9\u30e1\u30a4\u30f3\u306e\u30bb\u30b0\u30e1\u30f3\u30c8 1 \u500b\u3042\u305f\u308a\u306e\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u53ce\u7e2e\u306e\u51fa\u529b\u306f 6 pN \u3067\u3042\u308b\u3053\u3068\uff0c\u30df\u30aa\u30b7\u30f3\u30e2\u30fc\u30bf\u30fc 1 \u500b\u3042\u305f\u308a\u306e\u51fa\u529b\u3082 6 pN \u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u305f\uff08<a href=\"https:\/\/www.muscle-hypertrophy.com\/?p=3488\" rel=\"noopener\" target=\"_blank\">\u7b4b\u53ce\u7e2e\u306b\u304a\u3051\u308b\u4e3b\u8981\u306a\u99c6\u52d5\u529b\u3068\u3057\u3066\u306e\u30bf\u30a4\u30c1\u30f3\u86cb\u767d\u306e\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u306e\u50cd\u304d<\/a>\uff09\uff0e\u305f\u3060\u3057\uff0c\u3053\u308c\u3089\u306f\u3059\u3079\u3066\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u30bf\u30a4\u30c1\u30f3\u306e\u5358\u5206\u5b50\u306e\u5b9f\u9a13\u7cfb\u3067\u3042\u308a\uff0c\u751f\u4f53\u5185\u3067\u76f4\u63a5\u30bf\u30a4\u30c1\u30f3\u306e\u6319\u52d5\u3092\u89b3\u5bdf\u30fb\u6e2c\u5b9a\u3057\u305f\u3082\u306e\u3067\u306f\u306a\u3044\uff0e<\/p>\n<p>\u3000\u73fe\u5b9f\u306b\u7b4b\u7d30\u80de\u5185\u3067\u8d77\u304d\u3066\u3044\u308b\u30a2\u30af\u30c1\u30f3\uff0c\u30df\u30aa\u30b7\u30f3\uff0c\u30bf\u30a4\u30c1\u30f3\u306e\u6319\u52d5\u306f\u307e\u3060\u76f4\u63a5\u306b\u306f\u89b3\u5bdf\u3055\u308c\u3066\u3044\u306a\u3044\uff0e\u5358\u5206\u5b50\u3067\u306e\u6319\u52d5\u3068\u30b7\u30b9\u30c6\u30e0\u3068\u3057\u3066\u306e\u5206\u5b50\u8907\u5408\u4f53\u306e\u6319\u52d5\u3068\u304c\u7570\u306a\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u3082\u3042\u308b\uff0e\u5b9f\u969b\u306b\u30df\u30aa\u30b7\u30f3\u30e2\u30fc\u30bf\u30fc\u3068\u30bf\u30a4\u30c1\u30f3\u3068\u304c\u3069\u306e\u3088\u3046\u306a\u6a5f\u5e8f\u3067\u4f5c\u52d5\u3057\u3066\u3044\u308b\u306e\u304b\uff0c\u751f\u4f53\u5185\u3067\u76f4\u63a5\u89b3\u6e2c\u304c\u53ef\u80fd\u306b\u306a\u3063\u305f\u6642\uff0c\u7b4b\u53ce\u7e2e\u306b\u304a\u3051\u308b\u5206\u5b50\u30ec\u30d9\u30eb\u306e\u7406\u89e3\u304c\u4e00\u5b9a\u306e\u6bb5\u968e\u306b\u9054\u3059\u308b\u3082\u306e\u3068\u601d\u308f\u308c\u308b\uff0e\u4eca\u5f8c\u306e\u7814\u7a76\u304c\u5f85\u305f\u308c\u308b\uff0e<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3000\u7b4b\u30c8\u30ec\u306e\u5206\u5b50\u751f\u7269\u5b66\u30b7\u30ea\u30fc\u30ba\u7b2c 5 \u5f3e\uff0e\u7b4b\u53ce\u7e2e\u306e\u4e3b\u4f53\u3067\u3042\u308b\u30a2\u30af\u30c1\u30f3\u3068\u30df\u30aa\u30b7\u30f3\u306b\u3064\u3044\u3066\uff0e\u30bf\u30a4\u30c1\u30f3\u306b\u3064\u3044\u3066\u6700\u8fd1\u5206\u304b\u3063\u3066\u304d\u305f\u70b9\u306b\u3082\u8a00\u53ca\u3059\u308b\uff0e\u5c71\u672c\u7fa9\u5fb3\u30aa\u30d5\u30a3\u30b7\u30e3\u30eb\u30d6\u30ed\u30b0\u306f\u5b66\u8853\u7684\u306b\u3082\u8a73\u7d30\u306a\u3053\u3068\u3067\u6709\u540d\u3067\u3042\u308b\u304c, 2018 \u5e74 9 \u6708 &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.muscle-hypertrophy.com\/?p=3245\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;\u7b4b\u30c8\u30ec\u306e\u5206\u5b50\u751f\u7269\u5b66(5)\u30a2\u30af\u30c1\u30f3\u3068\u30df\u30aa\u30b7\u30f3\uff0c\u30bf\u30a4\u30c1\u30f3&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":3510,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[2405,72,2050,2044,2267,2399,2121,102,2068,2391,2170,104,2295,2200,129,70,2037,2045,2388,2390,2299,2206,2389,2402,2224,2166,97,101,2049,88,2291,2397,2301,71,130,2040,2270,2262,2041,2038,1501,2404,2047,2400,2403,2392,1636,2167,2042,2396,2043,2297,2393,233,2207,2069,2407,2036,2401,2079,2039,2260,2280,120,2271,2261,1500,95,103,2035,2046,2406,2272,2179,2398,2395,1687,2259,2048,2394],"class_list":{"0":"post-3245","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","6":"hentry","7":"category-resistance-training","8":"tag-a-v-hill","9":"tag-atp","10":"tag-atpca2","12":"tag-force-clamp","13":"tag-force-extension-curves","14":"tag-ig","15":"tag-ii","16":"tag-pevk","18":"tag-titin-folding","19":"tag-t","20":"tag-v","21":"tag-winding-filament","22":"tag-129","23":"tag-70","24":"tag-2037","25":"tag-2045","26":"tag-2388","27":"tag-2390","28":"tag-2299","29":"tag-2206","30":"tag-2389","31":"tag-2402","32":"tag-2224","33":"tag-2166","34":"tag-97","35":"tag-101","36":"tag-2049","37":"tag-88","38":"tag-2291","39":"tag-2397","40":"tag-2301","41":"tag-71","42":"tag-130","43":"tag-2040","44":"tag-2270","45":"tag-2262","46":"tag-2041","47":"tag-2038","48":"tag-1501","49":"tag-2404","50":"tag-2047","51":"tag-2400","52":"tag-2403","53":"tag-2392","54":"tag-1636","55":"tag-2167","56":"tag-2042","57":"tag-2396","58":"tag-2043","59":"tag-2297","60":"tag-2393","61":"tag-233","62":"tag-2207","63":"tag-2069","64":"tag-2407","65":"tag-2036","66":"tag-2401","67":"tag-2079","68":"tag-2039","69":"tag-2260","70":"tag-2280","71":"tag-120","72":"tag-2271","73":"tag-2261","74":"tag-1500","75":"tag-95","76":"tag-103","77":"tag-2035","78":"tag-2046","79":"tag-2406","80":"tag-2272","81":"tag-2179","82":"tag-2398","83":"tag-2395","84":"tag-ca2","85":"tag-2259","86":"tag-2048","87":"tag-2394"},"_links":{"self":[{"href":"https:\/\/www.muscle-hypertrophy.com\/index.php?rest_route=\/wp\/v2\/posts\/3245","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.muscle-hypertrophy.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.muscle-hypertrophy.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.muscle-hypertrophy.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.muscle-hypertrophy.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3245"}],"version-history":[{"count":54,"href":"https:\/\/www.muscle-hypertrophy.com\/index.php?rest_route=\/wp\/v2\/posts\/3245\/revisions"}],"predecessor-version":[{"id":3905,"href":"https:\/\/www.muscle-hypertrophy.com\/index.php?rest_route=\/wp\/v2\/posts\/3245\/revisions\/3905"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.muscle-hypertrophy.com\/index.php?rest_route=\/wp\/v2\/media\/3510"}],"wp:attachment":[{"href":"https:\/\/www.muscle-hypertrophy.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3245"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.muscle-hypertrophy.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3245"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.muscle-hypertrophy.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3245"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}