\u3000\u3053\u306e\u8ad6\u6587\u306e\u8457\u8005\u306f\u30b3\u30da\u30f3\u30cf\u30fc\u30b2\u30f3\u5927\u5b66\u306e Bente Klarlund Pedersen \u535a\u58eb<\/a>\u3060\u304c\uff0c\u8ad6\u6587\u5f15\u7528\u306e\u9806\u756a\u304c\u304d\u3061\u3093\u3068\u6587\u7ae0\u901a\u308a\u306b\u306a\u3063\u3066\u3044\u3066\u975e\u5e38\u306b\u8aad\u307f\u3084\u3059\u3044\uff0e\u666e\u901a\u306e\u8ad6\u6587\u3060\u3068\u5f15\u7528\u306e\u9806\u756a\u304c\u3050\u3061\u3083\u3050\u3061\u3083\u3067\u5927\u5909\u8aad\u307f\u306b\u304f\u3044\u306e\u3060\u304c\uff0c\u304d\u3061\u3093\u3068\u3057\u305f\u4eba\u306a\u3093\u3060\u308d\u3046\u306a\u3068\u601d\u308f\u3055\u308c\u308b\uff0e\u3044\u3084\uff0c\u3069\u3046\u3067\u3082\u3044\u3044\u3093\u3060\u3051\u3069\u306d\uff0e<\/p>\n <\/p>\n During the past decade, skeletal muscle has been identified as a secretory organ. Accordingly, we have suggested that cytokines and other peptides that are produced, expressed and released by muscle fibres and exert either autocrine, paracrine or endocrine effects should be classified as myokines. The finding that the muscle secretome consists of several hundred secreted peptides provides a conceptual basis and a whole new paradigm for understanding how muscles communicate with other organs, such as adipose tissue, liver, pancreas, bones and brain. However, some myokines exert their effects within the muscle itself. Thus, myostatin, LIF, IL-6 and IL-7 are involved in muscle hypertrophy and myogenesis, whereas BDNF and IL-6 are involved in AMPK-mediated fat oxidation. IL-6 also appears to have systemic effects on the liver, adipose tissue and the immune system, and mediates crosstalk between intestinal L cells and pancreatic islets. Other myokines include the osteogenic factors IGF-1 and FGF-2; FSTL-1, which improves the endothelial function of the vascular system; and the PGC-1\u03b1-dependent myokine irisin, which drives brown-fat-like development. Studies in the past few years suggest the existence of yet unidentified factors, secreted from muscle cells, which may influence cancer cell growth and pancreas function. Many proteins produced by skeletal muscle are dependent upon contraction; therefore, physical inactivity probably leads to an altered myokine response, which could provide a potential mechanism for the association between sedentary behaviour and many chronic diseases.<\/p>\n \u3000\u904e\u53bb 10 \u5e74\u9593\u3067\uff0c\u9aa8\u683c\u7b4b\u306f\u5206\u6ccc\u81d3\u5668\u3067\u3042\u308b\u3068\u540c\u5b9a\u3055\u308c\u305f\uff0e\u3086\u3048\u306b\u6211\u3005\u306f\u63d0\u6848\u3057\u3066\u304d\u305f\uff0e\u3064\u307e\u308a\uff0c\u7b4b\u7dda\u7dad\u306b\u3088\u3063\u3066\u7523\u751f\u3055\u308c\uff0c\u767a\u73fe\u3055\u308c\uff0c\u653e\u51fa\u3055\u308c\uff0c\u81ea\u5df1\u5206\u6ccc\uff0c\u508d\u5206\u6ccc\u307e\u305f\u306f\u5185\u5206\u6ccc\u306e\u3044\u305a\u308c\u304b\u306e\u4f5c\u7528\u3092\u767a\u63ee\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u304a\u3088\u3073\u4ed6\u306e\u30da\u30d7\u30c1\u30c9\u306f\uff0c\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u3068\u3057\u3066\u5206\u985e\u3055\u308c\u308b\u3079\u304d\u3067\u3042\u308b\u3068\uff0e\u7b4b\u5206\u6ccc\u7d30\u80de\u304c\u6570\u767e\u500b\u306e\u5206\u6ccc\u30da\u30d7\u30c1\u30c9\u304b\u3089\u306a\u308b\u3068\u3044\u3046\u77e5\u898b\u306f\uff0c\u8102\u80aa\u7d44\u7e54\uff0c\u809d\u81d3\uff0c\u81b5\u81d3\uff0c\u9aa8\u304a\u3088\u3073\u8133\u306e\u3088\u3046\u306a\u4ed6\u306e\u81d3\u5668\u3068\u7b4b\u8089\u304c\u3069\u306e\u3088\u3046\u306b\u4f1a\u8a71\u3059\u308b\u304b\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306e\u6982\u5ff5\u7684\u6839\u62e0\u304a\u3088\u3073\u5168\u304f\u65b0\u3057\u3044\u30d1\u30e9\u30c0\u30a4\u30e0\u3092\u63d0\u4f9b\u3059\u308b\uff0e\u3057\u304b\u3057\uff0c\u4e00\u90e8\u306e\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u306f\u7b4b\u8089\u81ea\u4f53\u306b\u5bfe\u3057\u3066\u305d\u306e\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\uff0e\u3057\u305f\u304c\u3063\u3066\uff0c\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\uff0cLIF, IL-6 \u304a\u3088\u3073 IL-7 \u306f\uff0c\u7b4b\u80a5\u5927\u304a\u3088\u3073\u7b4b\u5f62\u6210\u306b\u95a2\u4e0e\u3059\u308b\u304c\uff0cBDNF \u304a\u3088\u3073 IL-6 \u306f\uff0cAMPK \u3092\u4ecb\u3059\u308b\u8102\u8cea\u9178\u5316\u306b\u95a2\u4e0e\u3059\u308b\uff0eIL-6 \u306f\u307e\u305f\uff0c\u809d\u81d3\uff0c\u8102\u80aa\u7d44\u7e54\u304a\u3088\u3073\u514d\u75ab\u7cfb\u306b\u5168\u8eab\u4f5c\u7528\u3092\u53ca\u307c\u3057\uff0c\u8178\u7ba1 L \u7d30\u80de\u3068\u81b5\u5cf6\u3068\u306e\u9593\u306e\u30af\u30ed\u30b9\u30c8\u30fc\u30af\u3092\u5a92\u4ecb\u3059\u308b\uff0e\u4ed6\u306e\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u306b\u306f\uff0c\u9aa8\u5f62\u6210\u56e0\u5b50 IGF-1 \u304a\u3088\u3073 FGF-2 \u304c\u542b\u307e\u308c\u308b\uff0eFSTL-1 \u306f\u8840\u7ba1\u7cfb\u306e\u5185\u76ae\u6a5f\u80fd\u3092\u6539\u5584\u3059\u308b\uff0ePGC-1\u03b1 \u4f9d\u5b58\u6027\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u3067\u3042\u308b\u30a2\u30a4\u30ea\u30b7\u30f3\u306f\u8910\u8272\u8102\u80aa\u69d8\u306e\u5206\u5316\u3092\u3082\u305f\u3089\u3059\uff0e\u904e\u53bb\u6570\u5e74\u9593\u306e\u7814\u7a76\u306f\uff0c\u7b4b\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u307e\u3060\u540c\u5b9a\u3055\u308c\u3066\u3044\u306a\u3044\u56e0\u5b50\u306e\u5b58\u5728\u3092\u793a\u5506\u3057\u3066\u304a\u308a\uff0c\u764c\u7d30\u80de\u5897\u6b96\u304a\u3088\u3073\u81b5\u81d3\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\uff0e\u9aa8\u683c\u7b4b\u306b\u3088\u3063\u3066\u7523\u751f\u3055\u308c\u308b\u591a\u304f\u306e\u86cb\u767d\u8cea\u306f\u53ce\u7e2e\u306b\u4f9d\u5b58\u3059\u308b\uff0e\u3057\u305f\u304c\u3063\u3066\uff0c\u904b\u52d5\u4e0d\u8db3\u306f\u304a\u305d\u3089\u304f\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u5fdc\u7b54\u3092\u5909\u5316\u3055\u305b\uff0c\u3053\u308c\u306f\u5ea7\u4f4d\u884c\u52d5\u3068\u591a\u304f\u306e\u6162\u6027\u75be\u60a3\u3068\u306e\u9593\u306e\u95a2\u9023\u306e\u6f5c\u5728\u7684\u6a5f\u5e8f\u3092\u63d0\u4f9b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\uff0e<\/p>\n \u3000\u5065\u5e38\u4eba\u3068\u60a3\u8005\u306b\u304a\u3051\u308b\u4ee3\u8b1d\u306e\u30db\u30eb\u30e2\u30f3\u8abf\u7bc0\u306e\u89b3\u70b9\u306f\u904e\u53bb 20 \u5e74\u9593\u3067\u5927\u304d\u304f\u5909\u5316\u3057\u305f\uff0e\u305d\u308c\u306f\u4e3b\u306b\u8102\u80aa\u7d44\u7e54\u3078\u306e\u591a\u5927\u306a\u7814\u7a76\u306b\u8ca0\u3046\u3068\u3053\u308d\u304c\u5927\u304d\u3044\uff0e\u5f53\u521d\u306f\u4e2d\u6027\u8102\u80aa\u306e\u4e0d\u6d3b\u6027\u306a\u8caf\u8535\u5eab\u3060\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u305f\u304c\uff0c1980 \u5e74\u4ee3\u534a\u3070\u304b\u3089\u306e\u5148\u9032\u7684\u306a\u7814\u7a76\u304c\uff0c\u8102\u80aa\u7d30\u80de\u306f\u7279\u7570\u7684\u306a\u5206\u6ccc\u86cb\u767d\u3067\u88dc\u4f53\u56e0\u5b50 D \u307e\u305f\u306f\u30a2\u30c7\u30a3\u30b7\u30f3\u3068\u547c\u3070\u308c\u308b\u3082\u306e\u3092\u8c4a\u5bcc\u306b\u542b\u3080\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u305f (1<\/a>). 10 \u5e74\u4ee5\u4e0a\u524d\uff0c\u753b\u671f\u7684\u306a\u767a\u898b\u3067\uff0cZhang \u3089\u306f\u30ec\u30d7\u30c1\u30f3\u3092\u540c\u5b9a\u3057\u305f (2<\/a>). \u3053\u308c\u306f\u8102\u80aa\u7d30\u80de\u306b\u7279\u7570\u7684\u306a\u56e0\u5b50\u3067\u80a5\u6e80 ob\/ob \u30de\u30a6\u30b9\u3067\u6b20\u640d\u3057\u3066\u3044\u308b\u3082\u306e\u3067\u3042\u308a\uff0c\u8102\u80aa\u7d44\u7e54\u3068\u8133\u306e\u9593\u3067\u6a19\u6e96\u7684\u306a\u30db\u30eb\u30e2\u30f3\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u4ef2\u4ecb\u3059\u308b\uff0e\u3086\u3048\u306b\uff0c\u30a2\u30c7\u30a3\u30dd\u30cd\u30af\u30c1\u30f3\uff0c\u30ec\u30b8\u30b9\u30c1\u30f3\uff0c\u30cb\u30b3\u30c1\u30f3\u30a2\u30df\u30c9\u30db\u30b9\u30db\u30ea\u30dc\u30b7\u30eb\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff08\u30f4\u30a3\u30b9\u30d5\u30a1\u30c1\u30f3\u3068\u3057\u3066\u77e5\u3089\u308c\u308b\uff09\u304a\u3088\u3073\u30ec\u30c1\u30ce\u30fc\u30eb\u7d50\u5408\u30bf\u30f3\u30d1\u30af 4 \u304c\uff0c\u30a2\u30c7\u30a3\u30dd\u30ab\u30a4\u30f3\u306e\u6210\u9577\u3059\u308b\u30ea\u30b9\u30c8\u306b\u8ffd\u52a0\u3055\u308c\u305f (3<\/a>). \u30a2\u30c7\u30a3\u30dd\u30ab\u30a4\u30f3\u306f\u4ee3\u8b1d\u7684\u306b\u6d3b\u6027\u306a\u7d44\u7e54\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u5faa\u74b0\u56e0\u5b50\u3068\u3057\u3066\u306e\u5f79\u5272\u306b\u95a2\u3057\u3066\u591a\u304f\u306e\u7814\u7a76\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u304d\u305f\uff0e\u3057\u304b\u3057\uff0c\u53ce\u7e2e\u306b\u304a\u3044\u3066\uff0c\u7b4b\u7d30\u80de\u306f\u751f\u7406\u5b66\u7684\u304a\u3088\u3073\u75c5\u614b\u751f\u7406\u5b66\u7684\u306b\u7d30\u80de\u9759\u6b62\u306b\u5bfe\u3059\u308b\u6700\u3082\u8457\u660e\u306a\u5909\u5316\u306e\u4e00\u3064\u3092\u53d7\u3051\u308b\u3053\u3068\u306f\u5f37\u8abf\u3057\u3066\u304a\u304f\u5fc5\u8981\u304c\u3042\u308b\uff0e\u3055\u3089\u306b\uff0c\u904b\u52d5\u306f\u4ee3\u8b1d\u3068\u4ed6\u306e\u8af8\u81d3\u5668\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\uff0e\u7b4b\u8089\u306f\uff0c\u305d\u308c\u3086\u3048\u306b\uff0c\u5c40\u6240\u7684\u306b\u3082\u5185\u5206\u6ccc\u52b9\u679c\u306b\u304a\u3044\u3066\u3082\uff0c\u5206\u6ccc\u5206\u5b50\u306e\u91cd\u8981\u306a\u6839\u6e90\u306e\u4ee3\u8868\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u3063\u305f\uff0e<\/p>\n \u3000\u30a2\u30c7\u30a3\u30dd\u30cd\u30af\u30c1\u30f3\u4ee5\u5916\u306f (4<\/a>), \u8102\u80aa\u7d30\u80de\u306b\u3088\u308a\u7523\u751f\u3055\u308c\u308b\u56e0\u5b50\u306e\u5927\u90e8\u5206\u306f\u708e\u75c7\u8a98\u767a\u6027\u3067\u3042\u308b\uff0e\u4f8b\u3048\u3070\uff0cTNF, CCL2, PAI-1 \u306a\u3069\uff0c\u80a5\u6e80\u8a98\u767a\u6027\u306e\u4ee3\u8b1d\u6027\u75be\u60a3\u304a\u3088\u3073\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u9032\u5c55\u306b\u95a2\u3057\u3066\u6f5c\u5728\u7684\u306b\u6709\u5bb3\u3067\u3042\u308b\uff0e\u3053\u306e\u7406\u89e3\u306f\u91cd\u8981\u306a\u7591\u554f\u3092\u63d0\u8d77\u3057\u3066\u3044\u308b\uff0e\u3064\u307e\u308a\uff0c\u3069\u306e\u7d44\u7e54\u304c\u9632\u5fa1\u7684\u3067\uff0c\u8102\u80aa\u7d30\u80de\u306b\u3088\u308a\u7523\u751f\u3055\u308c\u308b\u708e\u75c7\u8a98\u767a\u56e0\u5b50\u306b\u5bfe\u3059\u308b\u30d0\u30e9\u30f3\u30b9\u3092\u53d6\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u304b\uff1f<\/p>\n \u3000\u77ed\u671f\u9593\u306e\u904b\u52d5\u4e0d\u8db3\u3067\u3055\u3048\u4ee3\u8b1d\u6027\u5909\u5316\u306b\u95a2\u9023\u3057\u3066\u304a\u308a\uff0c\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u4f4e\u4e0b\u3055\u305b\uff0c\u98df\u5f8c\u306e\u8102\u8cea\u4ee3\u8b1d\u3092\u6e1b\u5f31\u3055\u305b\uff0c\u7b4b\u8089\u91cf\u3092\u6e1b\u5c11\u3055\u305b\uff0c\u8840\u7ba1\u3078\u306e\u8102\u8cea\u6c88\u7740\u3092\u4fc3\u9032\u3059\u308b (5<\/a>,6<\/a>). \u3053\u306e\u3088\u3046\u306a\u7570\u5e38\u306f\u304a\u305d\u3089\u304f\u904b\u52d5\u306e\u6e1b\u5c11\u304c\u6162\u6027\u75be\u60a3\u306e\u9032\u884c\u3068\u65e9\u671f\u6b7b\u4ea1\u7387\u3068\u306e\u30ea\u30b9\u30af\u3092\u4e0a\u6607\u3055\u305b\u308b\u95a2\u9023\u6027\u3092\u4ee3\u8868\u3057\u3066\u3044\u308b (7<\/a>). \u904b\u52d5\u4e0d\u8db3\u306f 2 \u578b\u7cd6\u5c3f\u75c5 (T2DM) \u306e\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b (8<\/a>), \u5fc3\u8840\u7ba1\u75be\u60a3 (9<\/a>), \u5927\u8178\u764c (10<\/a>), \u9589\u7d4c\u5f8c\u306e\u4e73\u764c (11<\/a>) \u304a\u3088\u3073\u9aa8\u7c97\u9b06\u75c7 (12<\/a>) \u306e\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\uff0e\u5408\u7406\u7684\u306a\u63d0\u6848\u306f\u3053\u3046\u3067\u3042\u308b\uff0e\u3064\u307e\u308a\uff0c\u9aa8\u683c\u7b4b\u304c\uff0c\u708e\u75c7\u8a98\u767a\u6027\u30a2\u30c7\u30a3\u30dd\u30ab\u30a4\u30f3\u306e\u6709\u5bb3\u306a\u52b9\u679c\u306b\u5bfe\u6297\u3059\u308b\u4f55\u3089\u304b\u306e\u86cb\u767d\u8cea\u3092\u5206\u6ccc\u3059\u308b\u3053\u3068\u3067\uff0c\u904b\u52d5\u306b\u3088\u308b\u4f55\u3089\u304b\u306e\u78ba\u7acb\u3055\u308c\u305f\u9632\u5fa1\u52b9\u679c\u3092\u4ef2\u4ecb\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u3082\u306e\u3067\u3042\u308b (Figure 1<\/strong>). <\/p>\n \u3000\u7b4b\u7d30\u80de\u304c\u3042\u308b\u6db2\u6027\u56e0\u5b50\u3092\u7523\u751f\u3057\u653e\u51fa\u3059\u308b\u3068\u3044\u3046\u30a2\u30a4\u30c7\u30a2\u306f\uff0c\u8102\u80aa\u7d44\u7e54\u304c\u5206\u6ccc\u81d3\u5668\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u305f\u3088\u308a\u3082\u6570\u5e74\u524d\u306b\u9061\u308b\uff0e\u904e\u53bb\u534a\u4e16\u7d00\u8fd1\u304f\u306b\u308f\u305f\u308a\uff0c\u7814\u7a76\u8005\u305f\u3061\u306f\u3053\u306e\u3088\u3046\u306b\u4eee\u5b9a\u3057\u3066\u304d\u305f\uff0e\u3064\u307e\u308a\uff0c\u9aa8\u683c\u7b4b\u304c\u300c\u6db2\u6027\u300d\u56e0\u5b50\u3092\u51e6\u7406\u3059\u308b\u306e\u306f\uff0c\u53ce\u7e2e\u306e\u9593\u3060\u3051\u30b0\u30eb\u30b3\u30fc\u30b9\u9700\u8981\u304c\u4ea2\u9032\u3059\u308b\u53cd\u5fdc\u306b\u304a\u3044\u3066\u653e\u51fa\u3055\u308c\u308b\u3082\u306e\u3067\u3042\u308b\u3068 (13<\/a>). \u73fe\u5728\u307e\u3067\uff0c\u3088\u308a\u6b63\u78ba\u306a\u77e5\u898b\u304c\u306a\u3044\u3053\u3068\u304b\u3089\uff0c\u307e\u3060\u540c\u5b9a\u3055\u308c\u3066\u3044\u306a\u3044\u53ce\u7e2e\u8a98\u767a\u6027\u56e0\u5b50\u306f ‘the work stimulus’ \u3084 ‘the work factor’ \u307e\u305f\u306f ‘the exercise factor’ \u3068\u540d\u4ed8\u3051\u3089\u308c\u305f (14<\/a>). <\/p>\n \u3000\u6211\u3005\u306e\u898b\u89e3\u3067\u306f\uff0c\u8907\u6570\u5f62\u306e ‘exercise factors’ \u306f\uff0c\u8907\u6570\u306e\u4ee3\u8b1d\u7684\u30fb\u751f\u7406\u5b66\u7684\u5909\u5316\u304c\u904b\u52d5\u306b\u3088\u308a\u8a98\u767a\u3055\u308c\u308b\u3068\u3044\u3046\u4e8b\u5b9f\u304b\u3089\uff0c\u3082\u3063\u3068\u9069\u7528\u53ef\u80fd\u3060\u308d\u3046\u3068\u601d\u308f\u308c\u308b\uff0e’Exercise factor’ \u306e\u6982\u5ff5\u306e\u521d\u671f\u306e\u898b\u89e3\u306f\u6b21\u306e\u4e8b\u5b9f\u306b\u57fa\u3065\u3044\u3066\u8ff0\u3079\u3089\u308c\u3066\u3044\u305f\uff0e\u3064\u307e\u308a\uff0c\u53ce\u7e2e\u4e2d\u306e\u9aa8\u683c\u7b4b\u306f\u4ed6\u306e\u81d3\u5668\u3067\u306e\u4ee3\u8b1d\u7684\u30fb\u751f\u7406\u5b66\u7684\u53cd\u5fdc\u3092\u4ef2\u4ecb\u3059\u308b\u304c\uff0c\u305d\u308c\u306f\u795e\u7d4c\u7cfb\u3092\u7d4c\u7531\u3057\u305f\u3082\u306e\u3067\u306f\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u308b\uff0e\u3059\u306a\u308f\u3061\uff0c\u810a\u9ac4\u640d\u50b7\u306e\u305f\u3081\u306b\u6c42\u5fc3\u6027\u30a4\u30f3\u30d1\u30eb\u30b9\u3082\u9060\u5fc3\u6027\u30a4\u30f3\u30d1\u30eb\u30b9\u3082\u306a\u3044\u9ebb\u75fa\u3057\u305f\u7b4b\u8089\u3092\u96fb\u6c17\u523a\u6fc0\u3059\u308b\u3053\u3068\u3067\uff0c\u640d\u50b7\u306e\u306a\u3044\u500b\u4f53\u3068\u540c\u7b49\u306e\u591a\u304f\u306e\u751f\u7406\u5b66\u7684\u5909\u5316\u3092\u8a98\u767a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u306e\u3067\u3042\u308b (15<\/a>,16<\/a>). \u9aa8\u683c\u7b4b\u306e\u53ce\u7e2e\u306f\uff0c\u305d\u308c\u3086\u3048\u306b\uff0c\u4ed6\u306e\u81d3\u5668\u3068\u4f53\u6db2\u6027\u56e0\u5b50\u3092\u4ecb\u3057\u3066\u4f1a\u8a71\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u306b\u9055\u3044\u306a\u304f\uff0c\u305d\u308c\u306f\u904b\u52d5\u4e2d\u306b\u5faa\u74b0\u5668\u7cfb\u306b\u653e\u51fa\u3055\u308c\u308b\u3082\u306e\u3067\u3042\u308d\u3046\uff0e\u305d\u306e\u3088\u3046\u306a\u56e0\u5b50\u306f\u76f4\u63a5\u307e\u305f\u306f\u9593\u63a5\u7684\u306b\u4ed6\u306e\u81d3\u5668\uff0c\u305f\u3068\u3048\u3070\u8102\u80aa\u7d44\u7e54\u3084\u809d\u81d3\uff0c\u5fc3\u8840\u7ba1\u7cfb\u3084\u8133\u306a\u3069\u306e\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u3063\u305f\uff0e<\/p>\n \u3000\u9aa8\u683c\u7b4b\u306f\u75e9\u305b\u305f\u7537\u5973\u306e\u4f53\u91cd\u306e\u7d04 40 % \u3092\u69cb\u6210\u3057\uff0c\u3086\u3048\u306b\uff0c\u80a5\u6e80\u3067\u306a\u3044\u30d2\u30c8\u306b\u304a\u3044\u3066\u6700\u5927\u306e\u81d3\u5668\u3092\u69cb\u6210\u3057\u3066\u3044\u308b\uff0e\u904e\u53bb 10 \u5e74\u9593\u306b\u304a\u3044\u3066\uff0c\u7b4b\u7d30\u80de\u306f\u9ad8\u3044\u5206\u6ccc\u80fd\u3092\u6709\u3059\u308b\u7d30\u80de\u3067\u3042\u308b\u3068\u540c\u5b9a\u3055\u308c\uff0c\u8102\u80aa\u7d30\u80de\u304c\u4e3b\u8981\u306a\u5185\u5206\u6ccc\u7d30\u80de\u3067\u3042\u308b\u3068\u306e\u6982\u5ff5\u3092\u652f\u6301\u3057\u3066\u3044\u308b\uff0e\u7b4b\u7d30\u80de\u306f\u6570\u767e\u7a2e\u3082\u306e\u5206\u6ccc\u56e0\u5b50\u3092\u7523\u751f\u3059\u308b\u80fd\u529b\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b (17<\/a>,18<\/a>,19<\/a>). 2003 \u5e74\uff0cPedersen \u3089\u306f\uff0c\u7b4b\u7dda\u7dad\u306b\u3088\u308a\u7523\u751f\u3055\u308c\uff0c\u767a\u73fe\u3055\u308c\uff0c\u653e\u51fa\u3055\u308c\uff0c\u307e\u305f\u5185\u5206\u6ccc\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3084\u4ed6\u306e\u30da\u30d7\u30c1\u30c9\u3092\uff0c\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u3068\u3057\u3066\u5206\u985e\u3059\u3079\u304d\u3067\u3042\u308b\u3068\u63d0\u5531\u3057\u305f (14<\/a>). <\/p>\n \u3000\u9aa8\u683c\u7b4b\u3092\u5206\u6ccc\u81d3\u5668\u3068\u3057\u3066\u5b9a\u7fa9\u3059\u308b\u3053\u3068\u306f\u65b0\u3057\u3044\u30d1\u30e9\u30c0\u30a4\u30e0\u3092\u5275\u9020\u3057\u305f\uff0e\u7b4b\u8089\u306f\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u3092\u7523\u751f\u3057\uff0c\u653e\u51fa\u3059\u308b\uff0e\u305d\u308c\u306f\u30db\u30eb\u30e2\u30f3\u7528\u306e\u69d8\u5f0f\u3067\u4f5c\u7528\u3057\uff0c\u9060\u9694\u81d3\u5668\u306b\u5bfe\u3057\u3066\u7279\u7570\u7684\u306a\u5185\u5206\u6ccc\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\uff0e\u9aa8\u683c\u7b4b\u3067\u7523\u751f\u3055\u308c\u308b\u304c\u5faa\u74b0\u5668\u7cfb\u306b\u4e57\u3089\u306a\u3044\u4ed6\u306e\u86cb\u767d\u8cea\u306f\u30aa\u30fc\u30c8\u30af\u30ea\u30f3\u3084\u30d1\u30e9\u30af\u30ea\u30f3\u306e\u6a5f\u5e8f\u3092\u7d4c\u7531\u3057\u3066\u4f5c\u7528\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\uff0c\u7b4b\u8089\u81ea\u8eab\u306e\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b (20<\/a>,21<\/a>,22<\/a>,23<\/a>,24<\/a>,25<\/a>). \u3086\u3048\u306b\uff0c\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u306f\u904b\u52d5\u306b\u3088\u308b\u8907\u6570\u306e\u5065\u5eb7\u4e0a\u306e\u5229\u76ca\u3092\u4ef2\u4ecb\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\uff0e\u672c\u30ec\u30d3\u30e5\u30fc\u306f\u73fe\u5728\u307e\u3067\u306b\u540c\u5b9a\u3055\u308c\u305f\u7b4b\u7531\u6765\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u6700\u65b0\u7248\u3092\u63d0\u4f9b\u3059\u308b\u3082\u306e\u3067\u3042\u308b (Figure 2<\/strong>). \u3055\u3089\u306b\uff0c\u9aa8\u683c\u7b4b\u3092\u5185\u5206\u6ccc\u81d3\u5668\u3068\u3057\u3066\u5b9a\u7fa9\u3059\u308b\u3053\u3068\u306b\u306f\u81e8\u5e8a\u7684\u610f\u7fa9\u304c\u3042\u308b\uff0e\u305d\u308c\u306f\u672c\u30ec\u30d3\u30e5\u30fc\u3067\u30cf\u30a4\u30e9\u30a4\u30c8\u3059\u308b\u304c\uff0c\u9aa8\u683c\u7b4b\u304c\u6f14\u305a\u308b\u81d3\u5668\u540c\u58eb\u306e\u5bfe\u8a71\u306e\u4e2d\u6838\u3067\u3042\u308a\uff0c\u7b4b\u8089\u3068\u809d\u81d3\u304a\u3088\u3073\u7b4b\u8089\u3068\u8102\u80aa\u7d44\u7e54\u306e\u5bfe\u8a71\u3092\u542b\u3080\u3082\u306e\u3067\u3042\u308b\uff0e<\/p>\n \u3000\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\uff08\u6210\u9577\/\u5206\u5316\u56e0\u5b50 8 \u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u308b\uff09\u306f\uff0c\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u306e\u5b9a\u7fa9\u3092\u6e80\u305f\u3057\u305f\u6700\u521d\u306e\u7b4b\u8089\u5206\u6ccc\u56e0\u5b50\u3067\u3042\u308b\uff0e\u3053\u306e\u86cb\u767d\u8cea\u306f\u5faa\u74b0\u5668\u7cfb\u306b\u5206\u6ccc\u3055\u308c\u308b\uff0e\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u306f\u9ad8\u5ea6\u306b\u4fdd\u5b58\u3055\u308c\u305f TGF-β \u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u4e00\u54e1\u3067\u3042\u308a\uff0c\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u907a\u4f1d\u5b50\u306e\u4e0d\u6d3b\u6027\u5316\uff08\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\uff09\u306f\u30de\u30a6\u30b9 (26<\/a>), \u30a6\u30b7\u304a\u3088\u3073\u30d2\u30c8 (27<\/a>) \u306b\u304a\u3044\u3066\u8457\u660e\u306a\u7b4b\u80a5\u5927\u3092\u3082\u305f\u3089\u3059\uff0e\u9aa8\u683c\u7b4b\u306e\u6210\u9577\u306b\u304a\u3051\u308b\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u306e\u5236\u5fa1\u306e\u5f79\u5272\u306b\u52a0\u3048\u3066\uff0c\u3053\u306e\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u306f\u307e\u305f\u4ee3\u8b1d\u306e\u6052\u5e38\u6027\u304a\u3088\u3073\u8102\u80aa\u7d44\u7e54\u306e\u6a5f\u80fd\u3068\u91cf\u3092\u4fee\u98fe\u3059\u308b\u8abf\u6574\u306b\u3082\u95a2\u9023\u3057\u3066\u3044\u308b (28<\/a>,29<\/a>,30<\/a>,31<\/a>). \u30de\u30a6\u30b9\u3067\u306e\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u6b20\u640d\u306f\u4ed8\u968f\u7684\u306b\u9aa8\u683c\u7b4b\u80a5\u5927\u3092\u3082\u305f\u3089\u3057\uff0c\u5168\u8eab\u8102\u80aa\u7d44\u7e54\u306e\u6e1b\u5c11\u3092\u3082\u305f\u3089\u3059 (32<\/a>,33<\/a>). <\/p>\n \u3000\u30d2\u30c8\u304a\u3088\u3073\u3052\u3063\u6b6f\u985e\u306b\u304a\u3044\u3066\uff0c\u597d\u6c17\u6027\u304a\u3088\u3073\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306f\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u767a\u73fe\u3092\u6e1b\u5c11\u3055\u305b\u308b\u4e00\u65b9\u3067\uff0c\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u306e\u4e0d\u6d3b\u6027\u5316\u306f\u4ee3\u8b1d\u7684\u306b\u6301\u4e45\u6027\u904b\u52d5\u306e\u6709\u76ca\u306a\u52b9\u679c\u3092\u5897\u5f37\u3059\u308b\u3088\u3046\u306b\u898b\u3048\u308b (34<\/a>). \u80a5\u6e80\u304c\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u767a\u73fe\u306e\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u3044\u304f\u3064\u304b\u8a3c\u660e\u3055\u308c\u3066\u3044\u308b\uff0e\u7b4b\u8089\u3068\u5faa\u74b0\u7cfb\u5185\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u86cb\u767d\u91cf\u304c\u80a5\u6e80\u500b\u4f53\u3067\u306f\u5897\u52a0\u3057\u3066\u304a\u308a\uff0c\u3055\u3089\u306b\uff0c\u7b4b\u7ba1\u304b\u3089\u306e\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u5206\u6ccc\u306f\u7b4b\u751f\u691c\u6a19\u672c\u304b\u3089\u5358\u96e2\u3055\u308c\u305f\u7b4b\u82bd\u7d30\u80de\u306b\u7531\u6765\u3057\u3066\u304a\u308a\uff0c\u75e9\u305b\u305f\u5973\u6027\u3088\u308a\u3082\u80a5\u6e80\u5973\u6027\u306b\u304a\u3044\u3066\u5897\u52a0\u3057\u3066\u3044\u308b (35<\/a>). <\/p>\n \u3000\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3\u306f TGF-β \u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u4ed6\u306e\u4e00\u54e1\u3067\u3042\u308b\u304c\uff0c\u9aa8\u683c\u7b4b\u306b\u304a\u3051\u308b\u5236\u5fa1\u306e\u67a0\u5272\u306b\u95a2\u3059\u308b\u81ea\u7136\u767a\u751f\u3059\u308b\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u963b\u5bb3\u56e0\u5b50\u3067\u3042\u308b\uff0e\u8840\u6e05\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3\u6fc3\u5ea6\u306f\u6025\u901f\u306a\u81ea\u8ee2\u8eca\u904b\u52d5\u5f8c\u306b\u5065\u5e38\u500b\u4f53\u3067\u4e0a\u6607\u3057\uff0c\u30d4\u30fc\u30af\u6fc3\u5ea6\u306f 7 \u500d\u306b\u9054\u3059\u308b\uff0e\u3057\u304b\u3057\uff0c\u904b\u52d5\u80a2\u3067\u306f\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3\u653e\u51fa\u306f\u8a8d\u3081\u3089\u308c\u305a\uff0c\u53ce\u7e2e\u4e2d\u306e\u9aa8\u683c\u7b4b\u304c\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3\u6e90\u3067\u306f\u306a\u3044\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u305f\uff0e\u30de\u30a6\u30b9\u306b\u6c34\u6cf3\u904b\u52d5\u3092\u3055\u305b\u305f\u969b\uff0c\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3 mRNA \u304a\u3088\u3073\u86cb\u767d\u767a\u73fe\u306e\u8457\u660e\u306a\u5897\u52a0\u304c\u8840\u6e05\u304a\u3088\u3073\u809d\u81d3\u3067\u8a8d\u3081\u3089\u308c\u305f\uff0e\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3\u306e\u5168\u8eab\u3067\u306e\u6fc3\u5ea6\u5897\u52a0\u306f\uff0c\u4e3b\u306b\u7b4b\u8089\u3067\u306e\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\u767a\u73fe\u306e\u904b\u52d5\u95a2\u9023\u5236\u5fa1\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\uff0e\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3\u306f\u304a\u305d\u3089\u304f\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u3068\u3057\u3066\u3067\u306f\u306a\u304f\u3080\u3057\u308d\u30d8\u30d1\u30c8\u30ab\u30a4\u30f3\u3068\u3057\u3066\u5206\u985e\u3055\u308c\u308b\u3079\u304d\u3060\u308d\u3046\u304c\uff0c\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u306f\u904b\u52d5\u4e2d\u304a\u3088\u3073\u904b\u52d5\u5f8c\u306e\u7b4b\u8089-\u809d\u81d3\u9593\u306e\u5bfe\u8a71\u306e\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b (36<\/a>). <\/p>\n \u3000\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3 IL-6 \u306f\u7b4b\u53ce\u7e2e\u306b\u53cd\u5fdc\u3057\u3066\u8840\u6db2\u4e2d\u306b\u5206\u6ccc\u3055\u308c\u308b\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u3068\u3057\u3066\u6700\u521d\u306b\u767a\u898b\u3055\u308c\u305f (23<\/a>). \u3053\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306f\u5076\u7136\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u3068\u3057\u3066\u767a\u898b\u3055\u308c\u305f\u3082\u306e\u3067\uff0c\u904b\u52d5\u6642\u9593\u304a\u3088\u3073\u904b\u52d5\u306b\u53c2\u52a0\u3059\u308b\u7b4b\u8089\u91cf\u306b\u6bd4\u4f8b\u3057\u3066\u6fc3\u5ea6\u304c\u6307\u6570\u95a2\u6570\u7684\u306b\u4e0a\u6607\u3059\u308b\uff0e\u3086\u3048\u306b\uff0c\u8840\u6e05 IL-6 \u6fc3\u5ea6\u306f\u904b\u52d5\u306b\u53cd\u5fdc\u3057\u3066 100 \u500d\u306b\u3082\u4e0a\u6607\u3059\u308b\u304c\uff0c\u305d\u308c\u307b\u3069\u5287\u7684\u3067\u306a\u3044\u5897\u52a0\u306a\u3089\u3082\u3063\u3068\u983b\u7e41\u306b\u3042\u308b (37<\/a>). IL-6 \u306f\u30d2\u30c8\u306e\u7b4b\u82bd\u7d30\u80de (38<\/a>,39<\/a>), \u30d2\u30c8\u57f9\u990a\u7b4b\u82bd\u7d30\u80de (40<\/a>), \u6210\u9577\u3057\u3066\u3044\u308b\u30cd\u30ba\u30df\u306e\u7b4b\u7dda\u7dad\u304a\u3088\u3073\u7b4b\u5e79\u7d30\u80de\uff08\u30b5\u30c6\u30e9\u30a4\u30c8\u7d30\u80de\uff09\u3067\u767a\u73fe\u3057\u3066\u3044\u308b (41<\/a>). \u52a0\u3048\u3066\uff0cIL-6 \u306f\u5065\u5e38\u500b\u4f53\u304a\u3088\u3073 2 \u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7531\u6765\u306e\u4e00\u6b21\u57f9\u990a\u30d2\u30c8\u7b4b\u8089\u7d30\u80de\u304b\u3089\u653e\u51fa\u3055\u308c\u3066\u3044\u308b (42<\/a>,43<\/a>). <\/p>\n \u3000\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\uff0c\u904b\u52d5\u4e2d\u306e\u5faa\u74b0\u5668\u7cfb\u306b\u304a\u3051\u308b IL-6 \u6fc3\u5ea6\u4e0a\u6607\u306f\u3044\u304b\u306a\u308b\u7b4b\u640d\u50b7\u306e\u5fb4\u5019\u3082\u4f34\u3063\u3066\u3044\u306a\u3044 (37<\/a>). \u4eca\u4e16\u7d00\u521d\u982d\u306b\u81f3\u308b\u307e\u3067\u306f\u4e00\u822c\u306b\u6b21\u306e\u3088\u3046\u306b\u8003\u3048\u3089\u308c\u3066\u3044\u305f\uff0e\u3064\u307e\u308a\uff0c\u904b\u52d5\u4e2d\u306e IL-6 \u6fc3\u5ea6\u4e0a\u6607\u306f\u514d\u75ab\u53cd\u5fdc\u306e\u7d50\u679c\u3067\u3042\u308a\uff0c\u4f5c\u52d5\u7b4b\u306e\u5c40\u6240\u7684\u306a\u640d\u50b7\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308a (44<\/a>), \u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304c\u3053\u306e\u5897\u52a0\u306e\u539f\u56e0\u3067\u3042\u308b\u3068 (45<\/a>). \u3057\u304b\u3057\uff0c\u5358\u7403\u3067\u306e IL-6 mRNA \u6fc3\u5ea6\u306f\u904b\u52d5\u306e\u7d50\u679c\u4e0a\u6607\u3057\u3066\u3044\u306a\u304b\u3063\u305f (46<\/a>). \u3053\u306e\u77e5\u898b\u306f\u86cb\u767d\u8cea\u6fc3\u5ea6\u3068\u3082\u4e00\u81f4\u3057\u3066\u3044\u305f (47<\/a>,48<\/a>). \u3053\u3093\u306b\u3061\uff0c\u7b4b\u7d30\u80de\u306f\u904b\u52d5\u4e2d\u306e IL-6 \u7523\u751f\u306e\u4e3b\u8981\u6e90\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b (49<\/a>). \u809d\u81d3\u3067 IL-6 \u3092\u9664\u53bb\u3059\u308b\u3053\u3068\u306f\u6b21\u306e\u6a5f\u5e8f\u3092\u69cb\u6210\u3057\u3066\u3044\u308b\uff0e\u3064\u307e\u308a\uff0c\u5faa\u74b0\u5668\u7cfb\u5185\u306e IL-6 \u6fc3\u5ea6\u306e\u6162\u6027\u7684\u306a\u4e0a\u6607\u306b\u3088\u308b\u4ee3\u8b1d\u7684\u306a\u8ca0\u306e\u52b9\u679c\u304c\u5236\u9650\u3055\u308c\u308b\u306e\u3067\u3042\u308b\uff0e<\/p>\n \u3000\u3044\u304f\u3064\u304b\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\uff0cIL-6 \u306f\u904b\u52d5\u4e2d\u306e\u7b4b\u7d30\u80de\u306b\u3088\u308b\u7523\u751f\u3055\u308c\u308b\u3068\u3044\u3046\u6982\u5ff5\u3092\u652f\u6301\u3057\u3066\u3044\u308b\uff0e\u7d30\u80de\u6838\u3067\u306e IL-6 \u8ee2\u5199\u7387\u304a\u3088\u3073 IL-6 mRNA \u6fc3\u5ea6\u306f\u904b\u52d5\u958b\u59cb\u304b\u3089 30 \u5206\u4ee5\u5185\u306b\u6025\u901f\u304b\u3064\u8457\u660e\u306b\u5897\u52a0\u3059\u308b (50<\/a>,51<\/a>). \u305d\u308c\u306e\u793a\u5506\u3059\u308b\u3068\u3053\u308d\u306f\uff0c\u53ce\u7e2e\u306b\u95a2\u9023\u3059\u308b\u3042\u308b\u56e0\u5b50\u304c\u7b4b\u7d30\u80de\u6838\u3067\u306e IL-6 \u8ee2\u5199\u306e\u8abf\u7bc0\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u308b\uff0e\u3055\u3089\u306a\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\uff0c\u7b4b\u7dda\u7dad\u81ea\u8eab\u304c IL-6 mRNA \u306e\u6e90\u305d\u306e\u3082\u306e\u3067\u3042\u308a\uff0cin situ \u30cf\u30a4\u30d6\u30ea\u30c0\u30a4\u30bc\u30fc\u30b7\u30e7\u30f3\u304a\u3088\u3073\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u67d3\u8272\u624b\u6cd5\u3067\u751f\u691c\u6a19\u672c\u304b\u3089\u5f97\u3089\u308c\u305f\u89e3\u6790\u306b\u3088\u308a\uff0c\u305d\u306e\u86cb\u767d\u8cea\u304c\u5f97\u3089\u308c\u305f\u3053\u3068\u3067\u3042\u308b (52<\/a>). \u5fae\u91cf\u900f\u6790\u7814\u7a76\u306e\u793a\u5506\u3059\u308b\u3068\u3053\u308d\u306f\uff0c\u53ce\u7e2e\u4e2d\u306e\u9aa8\u683c\u7b4b\u5185\u306e IL-6 \u6fc3\u5ea6\u306f\u5faa\u74b0\u5668\u7cfb\u3067\u898b\u51fa\u3055\u308c\u308b\u305d\u308c\u306e 5 \u500d\u304b\u3089 100 \u500d\u306b\u307e\u3067\u9054\u3059\u308b\u3053\u3068\u3068\uff0c\u904b\u52d5\u4e2d\u304a\u3088\u3073\u904b\u52d5\u5f8c\u306b\u9593\u8cea\u304a\u3088\u3073\u7b4b\u7dda\u7dad\u5185\u306b IL-6 \u304c\u84c4\u7a4d\u3059\u308b\u3068\u3044\u3046\u6982\u5ff5\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b (53<\/a>). \u52d5\u9759\u8108\u304a\u3088\u3073\u904b\u52d5\u4e2d\u306e\u4e0b\u80a2\u3092\u6a2a\u5207\u308b\u8840\u6d41\u306e IL-6 \u6fc3\u5ea6\u3092\u540c\u6642\u306b\u8a08\u6e2c\u3059\u308b\u3053\u3068\u3067\uff0c\u81a8\u5927\u306a\u91cf\u306e IL-6 \u304c\u904b\u52d5\u4e2d\u306e\u7b4b\u8089\u304b\u3089\u5faa\u74b0\u8840\u4e2d\u306b\u653e\u51fa\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u305f (54<\/a>). <\/p>\n \u3000\u30d2\u30c8\u306e\u9aa8\u683c\u7b4b\u306f\u4ee5\u4e0b\u306e\u70b9\u3067\u30e6\u30cb\u30fc\u30af\u3067\u3042\u308b\uff0e\u3064\u307e\u308a TNF \u975e\u4f9d\u5b58\u69d8\u5f0f\u3067\u53b3\u5bc6\u306b\u53ce\u7e2e\u4e2d\u306b IL-6 \u3092\u7523\u751f\u3067\u304d\u308b (40<\/a>). \u3053\u306e\u77e5\u898b\u306e\u793a\u5506\u3059\u308b\u3068\u3053\u308d\u306f\uff0c\u7b4b\u7531\u6765 IL-6 \u306f\u708e\u75c7\u3088\u308a\u3080\u3057\u308d\u4ee3\u8b1d\u306b\u304a\u3051\u308b\u5f79\u5272\u3092\u6709\u3057\u3066\u3044\u308b\u3053\u3068\u3067\u3042\u308b\uff0e\u3053\u306e\u4eee\u5b9a\u3092\u652f\u6301\u3059\u308b\u3088\u3046\u306b\uff0c\u7b4b\u8089\u5185\u30b0\u30ea\u30b3\u30fc\u30b2\u30f3\u6fc3\u5ea6\u304c\u4f4e\u3044\u6642\u306b\u306f\uff0c\u7b4b\u8089\u5185\u306e IL-6 mRNA \u767a\u73fe (55<\/a>) \u3068 IL-6 \u86cb\u767d\u653e\u51fa (56<\/a>) \u306e\u4e21\u8005\u306f\u8457\u660e\u306b\u5f37\u5316\u3055\u308c\u308b\uff0e\u3053\u308c\u306f IL-6 \u304c\u30a8\u30cd\u30eb\u30ae\u30fc\u30bb\u30f3\u30b5\u30fc\u3068\u3057\u3066\u50cd\u3044\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b (57<\/a>,58<\/a>,59<\/a>,60<\/a>). \u3053\u306e\u8003\u3048\u306f\u304a\u3073\u305f\u3060\u3057\u3044\u7814\u7a76\u306b\u3088\u3063\u3066\u652f\u6301\u3055\u308c\u3066\u304a\u308a\uff0c\u904b\u52d5\u4e2d\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u6442\u53d6\u304c\u904b\u52d5\u8a98\u767a\u6027\u8840\u6e05 IL-6 \u5897\u52a0\u3092\u6e1b\u8870\u3055\u305b\u308b\u3053\u3068\uff0c\u53ce\u7e2e\u4e2d\u306e\u30d2\u30c8\u9aa8\u683c\u7b4b\u304b\u3089\u306e IL-6 \u653e\u51fa\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u3066\u3044\u308b (23<\/a>,61<\/a>). <\/p>\n \u3000\u9aa8\u683c\u7b4b\u306f\u898f\u5247\u7684\u306a\u904b\u52d5\u306b\u53cd\u5fdc\u3057\u3066\u86cb\u767d\u8cea\u306e\u7a2e\u985e\u3068\u91cf\u3092\u5909\u66f4\u3059\u308b\u80fd\u529b\u306e\u3042\u308b\u7d44\u7e54\u3067\u3042\u308b\uff0e\u9aa8\u683c\u7b4b\u306b\u304a\u3051\u308b\u904b\u52d5\u8a98\u767a\u6027\u9069\u5fdc\u306f\uff0c\u904b\u52d5\u524d\u306e\u9aa8\u683c\u7b4b\u542b\u6709\u30b0\u30ea\u30b3\u30fc\u30b2\u30f3\u3092\u5897\u52a0\u3055\u305b, β \u9178\u5316\u306b\u95a2\u9023\u3059\u308b\u91cd\u8981\u306a\u9175\u7d20\u3092\u6d3b\u6027\u5316\u3055\u305b\uff0c\u8102\u80aa\u7d44\u7e54\u3092\u6d3b\u6027\u5316\u3057\u3066\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u306b\u3088\u308b\u8102\u80aa\u5206\u89e3\u3092\u5897\u52a0\u3055\u305b\uff0c\u3055\u3089\u306b\u7b4b\u8089\u5185\u306e\u4e2d\u6027\u8102\u80aa\u306e\u9178\u5316\u3092\u4ea2\u9032\u3059\u308b\uff0e\u7d50\u679c\u3068\u3057\u3066\uff0c\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3055\u308c\u305f\u9aa8\u683c\u7b4b\u306f\u8102\u80aa\u3092\u57fa\u8cea\u3068\u3057\u3066\u5229\u7528\u53ef\u80fd\u3068\u306a\u308a\uff0c\u904b\u52d5\u4e2d\u306e\u57fa\u8cea\u3068\u3057\u3066\u8840\u6e05\u304a\u3088\u3073\u7b4b\u8089\u5185\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u306b\u4f9d\u5b58\u3057\u306a\u304f\u306a\u308b (23<\/a>,62<\/a>). \u3044\u304f\u3064\u304b\u306e\u75ab\u5b66\u7814\u7a76\u304c\u5831\u544a\u3057\u305f\u3068\u3053\u308d\u306b\u3088\u308b\u3068\uff0c\u898f\u5247\u7684\u306a\u904b\u52d5\u3068\u5b89\u9759\u6642\u306e\u8840\u6e05 IL-6 \u3068\u306e\u9593\u306b\u306f\u8ca0\u306e\u76f8\u95a2\u304c\u307f\u3089\u308c\uff0c\u904b\u52d5\u304c\u6d3b\u767a\u306b\u306a\u308b\u307b\u3069 IL-6 \u6fc3\u5ea6\u306f\u4f4e\u304f\u306a\u3063\u305f (37<\/a>). \u5bfe\u7167\u7684\u306b IL-6 \u6fc3\u5ea6\u306e\u9ad8\u3044\u72b6\u614b\u306f\u904b\u52d5\u4e0d\u8db3\u304a\u3088\u3073\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u3068\u76f8\u95a2\u3057\u3066\u3044\u305f\uff0e\u3055\u3089\u306b\uff0c\u8840\u6e05 IL-6 \u304a\u3088\u3073\u7b4b\u7531\u6765 IL-6 mRNA \u6fc3\u5ea6\u306e\u904b\u52d5\u8a98\u767a\u6027\u5897\u52a0\u306f\uff0c\u6301\u4e45\u6027\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3067\u6e1b\u5c11\u3059\u308b (63<\/a>). <\/p>\n \u3000\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\uff0c\u5b89\u9759\u6642\u8840\u6e05 IL-6 \u6fc3\u5ea6\u306f\u6301\u4e45\u6027\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3067\u30c0\u30a6\u30f3\u30ec\u30ae\u30e5\u30ec\u30fc\u30c8\u3055\u308c\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\uff0c\u5b89\u9759\u6642\u306e\u7b4b\u8089\u306e IL-6Rα \u767a\u73fe\u306f\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30c8\u3055\u308c\u308b\uff0e\u6301\u4e45\u6027\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3078\u306e\u53cd\u5fdc\u3068\u3057\u3066\uff0c\u7b4b\u8089\u306b\u304a\u3051\u308b\u57fa\u5e95 IL-6Rα mRNA \u6fc3\u5ea6\u306f\u5897\u52a0\u3057\u3066 100% \u306b\u307e\u3067\u81f3\u308b (55<\/a>). \u3086\u3048\u306b\uff0c\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3067\u306f\uff0cIL-6 \u30c0\u30a6\u30f3\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u306f\u4e00\u90e8 IL-6Rα \u767a\u73fe\u5897\u52a0\u306b\u3088\u308a\u76f8\u6bba\u3055\u308c\uff0cIL-6 \u611f\u53d7\u6027\u304c\u4ea2\u9032\u3059\u308b\u3053\u3068\u306b\u306a\u308b\uff0e\u6211\u3005\u306e\u4eee\u5b9a\u3067\u306f\uff0c\u7b4b\u8089\u3092\u4f7f\u7528\u305b\u305a\u306b\u3044\u308b\u3068 IL-6 \u62b5\u6297\u6027\u304a\u3088\u3073\u5faa\u74b0\u8840\u4e2d IL-6 \u6fc3\u5ea6\u304c\u4e0a\u6607\u3057\uff0c\u305d\u308c\u3068\u4e26\u884c\u3057\u3066\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u5897\u52a0\u3057\u3066\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7\u3068\u306a\u308a\uff0c\u30ec\u30d7\u30c1\u30f3\u62b5\u6297\u6027\u304c\u5897\u52a0\u3057\u3066\u6162\u6027\u7684\u306b\u5faa\u74b0\u8840\u4e2d\u306e\u30ec\u30d7\u30c1\u30f3\u6fc3\u5ea6\u304c\u4e0a\u6607\u3059\u308b\u3053\u3068\u306b\u306a\u308b\uff0e<\/p>\n \u3000\u30e9\u30c3\u30c8\u306e\u7b4b\u7d30\u80de\u306b in vitro \u3067 IL-6 \u3092\u6025\u901f\u306b\u4f5c\u7528\u3055\u305b\u308b\u3068\uff0c\u57fa\u5e95\u72b6\u614b\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u304a\u3088\u3073\u30b0\u30eb\u30b3\u30fc\u30b9\u8f38\u9001\u4f53\u306e GLUT4 \u306e\u819c\u8f38\u9001\u304c\u4ea2\u9032\u3057\u305f (64<\/a>). \u3055\u3089\u306b IL-6 \u306f in vitro \u3067\u306e\u7b4b\u7d30\u80de\u3067\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u523a\u6fc0\u306b\u3088\u308b\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u3092\u4ea2\u9032\u3055\u305b\u305f\uff0e\u3053\u306e\u77e5\u898b\u306f\u81e8\u5e8a\u3068\u306e\u95a2\u9023\u6027\u3092\u793a\u3057\u3066\u304a\u308a\uff0c\u907a\u4f1d\u5b50\u7d44\u63db\u3048\u30d2\u30c8 IL-6 \u88fd\u5264\u3092\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7\u306e\u5065\u5e38\u500b\u4f53\u306b\u6ce8\u5c04\u3059\u308b\u3068\uff0c\u30b0\u30eb\u30b3\u30fc\u30b9\u30af\u30e9\u30f3\u30d7\u88c5\u7f6e\u3067\u306f\u5168\u8eab\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u4ea2\u9032\u3055\u305b\u305f\uff0eIL-6 \u3067\u306e\u51e6\u7f6e\u306b\u3088\u308a\uff0c\u5185\u56e0\u6027\u30b0\u30eb\u30b3\u30fc\u30b9\u7523\u751f\u306e\u7dcf\u91cf\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306a\u304f\u30b0\u30eb\u30b3\u30fc\u30b9\u6ce8\u5165\u91cf\u3092\u5897\u52a0\u3055\u305b\u305f\u306e\u3067\u3042\u308b (64<\/a>). In vitro \u3067\u306f IL-6 \u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u306b\u304a\u3051\u308b\u52b9\u679c\u306f AMPK \u6d3b\u6027\u5316\u3092\u4ecb\u3057\u3066\u767a\u73fe\u3057\u3066\u3044\u305f\u304c\uff0cdominant-negative AMPK \u3092\u767a\u73fe\u3059\u308b\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u3092\u611f\u67d3\u3055\u305b\u305f\u7b4b\u7d30\u80de\u3067\u306e\u7d50\u679c\u306f\u5ec3\u6b62\u3055\u308c\u305f (64<\/a>). <\/p>\n \u3000\u3044\u304f\u3064\u304b\u306e\u8a66\u9a13\u3067\u306f IL-6 \u306f\u307e\u305f\uff0c\u7b4b\u7d30\u80de\u5185 (64<\/a>,65<\/a>,66<\/a>) \u304a\u3088\u3073\u5168\u8eab (67<\/a>) \u306e\u8102\u80aa\u9178\u306e\u9178\u5316\u3092 AMPK \u3092\u4ecb\u3057\u3066\u4ea2\u9032\u3059\u308b (64<\/a>,68<\/a>) \u3088\u3046\u3067\u3042\u308b\uff0eIL-6 \u306f IL-6Rβ \u3092\u7d4c\u7531\u3057\u3066\u6025\u901f\u306b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3057\uff08\u3053\u308c\u306f\u7cd6\u86cb\u767d 130 [gp130] \u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u3066\u3044\u308b\uff09\uff0c\u591a\u304f\u306e\u30ec\u30d7\u30c1\u30f3\u69d8\u306e\u4f5c\u7528\u3092\u767a\u73fe\u3059\u308b\uff0e\u4f8b\u3068\u3057\u3066\u306f AMPK \u6d3b\u6027\u5316 (69<\/a>,70<\/a>,71<\/a>), \u30a4\u30f3\u30b9\u30ea\u30f3\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054 (72<\/a>) \u306a\u3069\u3067\u3042\u308b\uff0e\u8208\u5473\u6df1\u3044\u3053\u3068\u306b, IL-6 \u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306f\u9045\u767a\u6027\u306e\u80a5\u6e80\u3068\u8010\u7cd6\u80fd\u7570\u5e38\u3092\u767a\u75c7\u3059\u308b\u306e\u3060\u304c (73<\/a>), \u305d\u306e\u3053\u3068\u306f IL-6 \u304c\u4ee3\u8b1d\u306b\u304a\u3044\u3066\u6709\u76ca\u306a\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3068\u3044\u3046\u6982\u5ff5\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b\uff0e<\/p>\n \u3000\u91cd\u8981\u306a\u3053\u3068\u3068\u3057\u3066\uff0cIL-6 \u306f\u57fa\u672c\u7684\u306a\u751f\u7269\u5b66\u7684\u6d3b\u6027\u3092\u6709\u3059\u308b\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u3067\u3042\u308a\uff0c\u904b\u52d5\u4e2d\u306e\u809d\u81d3\u3067\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u7523\u751f\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b (74<\/a>). \u7b4b\u8089\u306e\u4f5c\u7528\u3059\u308b\u9593\u306b\u30b0\u30eb\u30b3\u30fc\u30b9\u304c\u7523\u751f\u3055\u308c\u9664\u53bb\u3055\u308c\u308b\u5805\u56fa\u306a\u5236\u5fa1\u306e\u6a5f\u5e8f\u306f\u4e0d\u660e\u3067\u3042\u308b\uff0e\u307e\u3060\u767a\u898b\u3055\u308c\u3066\u3044\u306a\u3044\uff0c\u5185\u56e0\u6027\u30b0\u30eb\u30b3\u30fc\u30b9\u7523\u751f\u306b\u304a\u3051\u308b\u53ce\u7e2e\u8a98\u767a\u6027\u5897\u52a0\u306b\u5f71\u97ff\u3059\u308b ‘work factor’ \u306e\u5b58\u5728\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\uff0e\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u30d2\u30c8 IL-6 \u88fd\u5264\u3092\u5b89\u9759\u72b6\u614b\u306e\u30d2\u30c8\u500b\u4f53\u306b\u6025\u901f\u9759\u6ce8\u3057\u3066\u751f\u7406\u5b66\u7684\u6fc3\u5ea6\u306b\u9054\u3057\u3066\u3082\uff0c\u5168\u8eab\u3067\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u51e6\u7406\uff0c\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u304a\u3088\u3073\u5185\u56e0\u6027\u30b0\u30eb\u30b3\u30fc\u30b9\u7523\u751f\u306b\u306f\u5f71\u97ff\u304c\u306a\u304b\u3063\u305f (66<\/a>,75<\/a>,76<\/a>). \u5bfe\u7167\u7684\u306b\uff0cIL-6 \u306f\u5185\u56e0\u6027\u30b0\u30eb\u30b3\u30fc\u30b9\u7523\u751f\u306e\u53ce\u7e2e\u95a2\u9023\u5897\u52a0\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\uff0e\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u30d2\u30c8 IL-6 \u88fd\u5264\u3092\u4f4e\u5f37\u5ea6\u3067\u904b\u52d5\u4e2d\u306e\u5065\u5eb7\u306a\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\u306b\u6295\u4e0e\u3057\u305f\u3068\u3053\u308d\uff0c\u76ee\u7684\u306f\u9ad8\u5f37\u5ea6\u3067\u306e\u904b\u52d5\u4e2d\u306b\u89b3\u6e2c\u3055\u308c\u308b\u5faa\u74b0\u8840\u4e2d\u306e IL-6 \u6fc3\u5ea6\u3092\u6a21\u5023\u3059\u308b\u3053\u3068\u306a\u306e\u3060\u304c\uff0c\u30b0\u30eb\u30b3\u30fc\u30b9\u51fa\u529b\u306f\u9ad8\u5f37\u5ea6\u3067\u306e\u904b\u52d5\u4e2d\u3068\u540c\u7b49\u306b\u9ad8\u304b\u3063\u305f\uff0e\u3053\u306e\u7814\u7a76\u306f\u7b4b\u8089\u3068\u809d\u81d3\u306e\u76f4\u63a5\u306e\u30af\u30ed\u30b9\u30c8\u30fc\u30af\u3092\u8a3c\u660e\u3057\u305f\u3082\u306e\u3067\u3042\u308b\uff0eIL-6 \u306f\u30d2\u30c8\u306b\u304a\u3051\u308b\u5185\u56e0\u6027\u30b0\u30eb\u30b3\u30fc\u30b9\u7523\u751f\u306e\u5f79\u5272\u3092\u6709\u3059\u308b\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u305f\uff0e\u3057\u304b\u3057\uff0c\u305d\u306e\u809d\u81d3\u3067\u306e\u4f5c\u7528\u306f\uff0c\u307e\u3060\u540c\u5b9a\u3055\u308c\u3066\u3044\u306a\u3044\u7b4b\u53ce\u7e2e\u8a98\u767a\u6027\u56e0\u5b50\u306b\u4f9d\u5b58\u3057\u3066\u3044\u308b (74<\/a>). <\/p>\n \u3000\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u30d2\u30c8 IL-6 \u88fd\u5264\u306e\u5065\u5eb7\u500b\u4f53\u3078\u306e\u6295\u4e0e\u306f\u8102\u80aa\u5206\u89e3\u306e\u5897\u52a0\u3092\u5f15\u304d\u8d77\u3053\u3057\u305f\u304c\uff0c\u9ad8\u4e2d\u6027\u8102\u80aa\u8840\u75c7\u3084\u30ab\u30c6\u30b3\u30e9\u30df\u30f3\uff0c\u30b0\u30eb\u30ab\u30b4\u30f3\uff0c\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u5909\u5316\u304a\u3088\u3073\u4ed6\u306e\u526f\u4f5c\u7528\u306f\u898b\u3089\u308c\u306a\u304b\u3063\u305f (66<\/a>,67<\/a>,76<\/a>). \u7d30\u80de\u57f9\u990a\u5b9f\u9a13\u3092\u542b\u3081\u305f\u3053\u308c\u3089\u306e\u77e5\u898b\u304b\u3089\u306f\uff0cIL-6 \u304c\u8102\u80aa\u5206\u89e3\u3068\u8102\u80aa\u9178\u9178\u5316\u306e\u4e21\u8005\u306b\u76f4\u63a5\u52b9\u679c\u3092\u6709\u3057\u3066\u304a\u308a\uff0cIL-6 \u306e\u540c\u5b9a\u306f\u8102\u80aa\u5206\u89e3\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b (66<\/a>). \u5065\u5eb7\u306a\u4eba\u306b IL-6 \u3092\u6295\u4e0e\u3057\u3066\u751f\u7406\u7684\u6fc3\u5ea6\u306b\u9054\u3059\u308b\u3068\uff0c\u4e3b\u306b\u9aa8\u683c\u7b4b\u3067\u306e\u8102\u80aa\u5206\u89e3\u304c\u523a\u6fc0\u3055\u308c\u308b\u304c\uff0c\u8102\u80aa\u7d44\u7e54\u306f\u5f71\u97ff\u3092\u53d7\u3051\u306a\u3044 (77<\/a>). <\/p>\n \u3000IL-6 \u306f\u304a\u305d\u3089\u304f\u904b\u52d5\u306b\u304a\u3051\u308b\u4f55\u3089\u304b\u306e\u6297\u708e\u75c7\u4f5c\u7528\u304a\u3088\u3073\u514d\u75ab\u8abf\u6574\u52b9\u679c\u3092\u4ecb\u3057\u3066\u3044\u308b (78<\/a>,79<\/a>). IL-6 \u306f\u30d2\u30c8\u57f9\u990a\u5358\u7403\u306b\u304a\u3044\u3066\u30ea\u30dd\u591a\u7cd6\u8a98\u767a\u6027 TNF \u7523\u751f\u3092\u963b\u5bb3\u3057 (80<\/a>), \u6297 IL-6 \u6297\u4f53\u3092\u6295\u4e0e\u3057\u305f\u30de\u30a6\u30b9\u3084 IL-6 \u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3067\u306f TNF \u6fc3\u5ea6\u304c\u8457\u660e\u306b\u4e0a\u6607\u3059\u308b\u304c (81<\/a>), \u305d\u308c\u306f\u5faa\u74b0\u8840\u4e2d IL-6 \u304c TNF \u6fc3\u5ea6\u306e\u5236\u5fa1\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\uff0e\u52a0\u3048\u3066\uff0c\u5065\u5eb7\u306a\u500b\u4f53\u3067\u306f\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048\u30d2\u30c8 IL-6 \u88fd\u5264\u6295\u4e0e\u3082\u904b\u52d5\u3082\u30a8\u30f3\u30c9\u30c8\u30ad\u30b7\u30f3\u8a98\u767a\u6027\u306e\u5faa\u74b0\u8840\u4e2d TNF \u6fc3\u5ea6\u306e\u4e0a\u6607\u3092\u963b\u5bb3\u3059\u308b (82<\/a>). IL-6 \u306e\u6297\u708e\u75c7\u52b9\u679c\u306f\u307e\u305f IL-6 \u304c\u53e4\u5178\u7684\u306a\u6297\u708e\u75c7\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308b IL-1ra \u304a\u3088\u3073 IL-10 \u306e\u7523\u751f\u3092\u523a\u6fc0\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u8a3c\u660e\u3055\u308c\u305f (83<\/a>). <\/p>\n \u3000Haugen \u3089\u306f IL-7 \u3092\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u3068\u3057\u3066\u540c\u5b9a\u3057\u305f (42<\/a>). IL-7 \u306f T \u7d30\u80de\u3068 B \u7d30\u80de\u306e\u5206\u5316\u306e\u969b\u306b\u8981\u6c42\u3055\u308c\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308b\u304c\uff0c\u4e00\u65b9\u3067\uff0c\u975e\u514d\u75ab\u7d30\u80de\u306b\u304a\u3051\u308b IL-7 \u306e\u53ef\u80fd\u6027\u306e\u3042\u308b\u751f\u7269\u5b66\u7684\u6a5f\u80fd\u306f\u63a2\u7d22\u3055\u308c\u3066\u3053\u306a\u304b\u3063\u305f\uff0eIL-7 mRNA \u304a\u3088\u3073\u86cb\u767d\u8cea\u306f\u4e3b\u306b\u30d2\u30c8\u57f9\u990a\u7b4b\u7ba1\u306e\u6761\u4ef6\u3064\u304d\u57f9\u5730\u304a\u3088\u3073\u7b4b\u7ba1\u304b\u3089\u691c\u51fa\u3055\u308c\u305f\uff0e\u57f9\u5730\u4e2d\u306e IL-7 \u306e\u91cf\u306f\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30b7\u30e7\u30f3\u6642\u9593\u3068\u5171\u306b\u5897\u52a0\u3057\u305f (42<\/a>). \u30d2\u30c8\u7b4b\u82bd\u7d30\u80de\u3092\u5206\u5316\u306e\u969b\u306b\u907a\u4f1d\u5b50\u7d44\u307f\u63db\u3048 IL-7 \u3068\u5171\u306b\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30b7\u30e7\u30f3\u3059\u308b\u3068\uff0c\u6700\u7d42\u7b4b\u5f62\u6210\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u30df\u30aa\u30b7\u30f3\u91cd\u9396 2 \u304a\u3088\u3073 myogenin \u306e mRNA \u6fc3\u5ea6\u306e\u6e1b\u5c11\u3092\u8a98\u5c0e\u3057\u305f\uff0e\u3053\u306e\u77e5\u898b\u306f IL-7 \u304c\u30b5\u30c6\u30e9\u30a4\u30c8\u7d30\u80de\u306b\u4f5c\u7528\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\uff0e\u30b5\u30c6\u30e9\u30a4\u30c8\u7d30\u80de\u3068\u306f\u6210\u719f\u7b4b\u7d30\u80de\u3067\u898b\u3064\u304b\u3063\u305f\u5c0f\u3055\u306a\u5358\u6838\u306e\u524d\u99c6\u7d30\u80de\u306e\u3053\u3068\u3067\u3042\u308b\uff0eHaugen \u3089\u306f\u307e\u305f\uff0c\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u7d4c\u9a13\u3057\u305f\u7537\u6027\u88ab\u691c\u8005\u306e\u5b89\u9759\u6642\u306e\u5916\u5074\u5e83\u7b4b\u304a\u3088\u3073\u50e7\u5e3d\u7b4b\u304b\u3089\u306e\u751f\u691c\u6a19\u672c\u306b\u304a\u3044\u3066\u7b4b\u8089\u3067\u306e IL-7 mRNA \u767a\u73fe\u304c\u6570\u500d\u306b\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u8a3c\u660e\u3057\u305f (42<\/a>). <\/p>\n \u3000IL-8 \u306f\u30b1\u30e2\u30ab\u30a4\u30f3\u306e\u5de8\u5927\u306a\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3059\u308b\uff0e\u3053\u306e\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u306f\u4e3b\u306b\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3068\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3067\u7523\u751f\u3055\u308c\uff0c\u767d\u8840\u7403\u904a\u8d70\u306e\u5f37\u529b\u306a\u6d3b\u6027\u3092\u767a\u63ee\u3057\uff0c\u3055\u3089\u306b\uff0c\u8840\u7ba1\u65b0\u751f\u56e0\u5b50\u3067\u3082\u3042\u308b\uff0e\u30cd\u30ba\u30df\u306e\u30b1\u30e2\u30ab\u30a4\u30f3\u3067\u3042\u308b CXC ligand 1 (CXCL-1) \u306f\u30d2\u30c8 CXCL-1 \u3068\u6700\u3082\u9ad8\u3044\u914d\u5217\u76f8\u540c\u6027\u3092\u6709\u3057\u3066\u304a\u308a\uff0c\u3057\u304b\u3057\u3057\u3070\u3057\u3070\u30d2\u30c8 IL-8 \u3068\u306e\u6a5f\u80fd\u7684\u76f8\u540c\u6027\u306b\u3064\u3044\u3066\u8a00\u53ca\u3055\u308c\u308b (84<\/a>). CXCL-1 \u304a\u3088\u3073 IL-8 \u306f\u597d\u4e2d\u7403\u904a\u8d70\u6d3b\u6027\u3092\u6709\u3057\u3066\u3044\u308b\uff0e\u3055\u3089\u306b\uff0c\u305d\u308c\u3089\u306f\u8840\u7ba1\u65b0\u751f\u306e\u904e\u7a0b\u306b\u3082\u95a2\u9023\u3057\u3066\u3044\u308b (85<\/a>). IL-8 \u306e\u8840\u7ba1\u65b0\u751f\u3092\u8a98\u767a\u3059\u308b\u80fd\u529b\u306f\u708e\u75c7\u3092\u8a98\u767a\u3059\u308b\u80fd\u529b\u3068\u306f\u7570\u306a\u308b (86<\/a>). IL-8 \u306f CXC \u30b1\u30e2\u30ab\u30a4\u30f3\u53d7\u5bb9\u4f53\u3067\u3042\u308b CXCR-1 \u304a\u3088\u3073 CXCR-2 \u306b\u7d50\u5408\u3059\u308b (87<\/a>). CXCR-2 \u306f\u30d2\u30c8\u6bdb\u7d30\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3067\u767a\u73fe\u3057\u3066\u304a\u308a\uff0cIL-8 \u8a98\u5c0e\u6027\u8840\u7ba1\u65b0\u751f\u306b\u5bfe\u5fdc\u3059\u308b\u53d7\u5bb9\u4f53\u3067\u3042\u308b (88<\/a>). <\/p>\n \u3000CXC \u30b1\u30e2\u30ab\u30a4\u30f3\u306e\u7570\u306a\u308b\u53d7\u5bb9\u4f53\u7523\u751f\u306f IL-6 \u306b\u3088\u308a\u8a98\u5c0e\u3055\u308c\u308b (89<\/a>). \u30cd\u30ba\u30df CXCL-1 \u306e\u8abf\u7bc0\u306b\u304a\u3051\u308b\u904b\u52d5\u3068 IL-6 \u306e\u5f79\u5272\u304c\uff0c\u305d\u308c\u3086\u3048\uff0c\u7814\u7a76\u3055\u308c\u3066\u304d\u305f (90<\/a>). 1 \u56de\u306e\u904b\u52d5\u5f8c\uff0cCXCL-1 mRNA \u6fc3\u5ea6\u304c\u8840\u6e05\uff0c\u7b4b\u8089\u304a\u3088\u3073\u809d\u81d3\u3067\u5897\u52a0\u3057\u305f\uff0e\u809d\u81d3\u3067\u306e CXCL-1 mRNA \u306e\u904b\u52d5\u8a98\u767a\u6027\u306e\u767a\u73fe\u306e\u8abf\u7bc0\u306f, IL-6 \u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3067\u306f\u5b8c\u5168\u306b\u920d\u304b\u3063\u305f\uff0eIL-6 \u304c\u904e\u5270\u767a\u73fe\u3057\u305f\u30cd\u30ba\u30df\u306e\u7b4b\u8089\u3067\u306f\u8840\u6e05 CXCL-1 \u304a\u3088\u3073\u809d\u81d3\u3067\u306e CXCL-1 mRNA \u767a\u73fe\u304c\u8457\u660e\u306b\u5897\u52a0\u3057\u3066\u3044\u305f\uff0e\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u306f\u904b\u52d5\u4e2d\u306e\u5805\u7262\u306a\u7b4b\u8089-\u809d\u81d3\u9593\u306e\u30af\u30ed\u30b9\u30c8\u30fc\u30af\u3092\u8a3c\u660e\u3059\u308b\u3082\u306e\u3067\u3042\u308a\uff0c\u904b\u52d5\u8a98\u767a\u6027\u306e IL-6 \u7523\u751f\u306f\u809d\u81d3\u3067\u306e CXCL-1 \u7523\u751f\u3092\u523a\u6fc0\u3059\u308b\u3082\u306e\u3067\u3042\u308b\uff0e\u305d\u306e\u7814\u7a76\u3067\u306f\u809d\u81d3\u3067\u306e CXCL-1 \u767a\u73fe\u304c\u7b4b\u8089\u3068\u6bd4\u8f03\u3057\u3066\u306f\u308b\u304b\u306b\u9ad8\u304b\u3063\u305f\uff0e\u3057\u304b\u3057\uff0c\u7b4b\u8089\u306e IL-8 mRNA \u6fc3\u5ea6\u306f\u904b\u52d5\u306b\u3088\u308a\u5897\u52a0\u3057 (91<\/a>), IL-8 \u306f\u30d2\u30c8\u4e00\u6b21\u57f9\u990a\u7b4b\u7ba1\u306b\u3088\u308a\u653e\u51fa\u3055\u308c\u308b (42<\/a>). \u809d\u7531\u6765\u304a\u3088\u3073\u7b4b\u7d30\u80de\u7531\u6765\u306e IL-8 \u306e\u751f\u7269\u5b66\u7684\u5f79\u5272\u306f\u5206\u304b\u3063\u3066\u3044\u306a\u3044\uff0e<\/p>\n \u3000LIF \u306f 1988 \u5e74\u306b\u8179\u6c34\u816b\u760d\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u86cb\u767d\u8cea\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u305f (92<\/a>). \u3053\u306e\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u306f IL-6 \u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3057\uff0c\u30cb\u30e5\u30fc\u30ed\u30dd\u30a4\u30a8\u30c1\u30f3\u3068\u3044\u3046\u540d\u306e\u86cb\u767d\u8cea (gp130) \u3068\u69cb\u9020\u7684\u306b\u3082\u6a5f\u80fd\u7684\u306b\u3082\u985e\u4f3c\u3057\u3066\u3044\u308b (93<\/a>). LIF \u306b\u306f\u591a\u69d8\u306a\u751f\u7269\u5b66\u7684\u6a5f\u80fd\u304c\u3042\u308a\uff0c\u8840\u5c0f\u677f\u5f62\u6210\u306e\u523a\u6fc0\uff0c\u9020\u8840\u7d30\u80de\u306e\u5897\u6b96\uff0c\u9aa8\u5f62\u6210\uff0c\u795e\u7d4c\u306e\u751f\u5b58\u304a\u3088\u3073\u5f62\u6210\uff0c\u305d\u3057\u3066\u809d\u7d30\u80de\u306b\u3088\u308b\u6025\u6027\u671f\u7523\u751f\u3067\u3042\u308b (94<\/a>). \u3055\u3089\u306b\uff0cLIF \u306f\u30b5\u30c6\u30e9\u30a4\u30c8\u7d30\u80de\u5897\u6b96\u3092\u8a98\u5c0e\u3057\uff0c\u305d\u308c\u306f\u7b4b\u80a5\u5927\u3068\u7b4b\u518d\u751f\u306b\u5fc5\u9808\u306e\u5f79\u5272\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b (95<\/a>). <\/p>\n \u3000LIF mRNA \u767a\u73fe\u306f\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u9593\u306b\u30d2\u30c8\u9aa8\u683c\u7b4b\u3067\u8a98\u5c0e\u3055\u308c\uff0cLIF \u86cb\u767d\u8cea\u306f\u30d2\u30c8\u57f9\u990a\u7b4b\u7ba1\u3092\u96fb\u6c17\u523a\u6fc0\u3057\u3066\u3082\u5206\u6ccc\u3055\u308c\u308b (96<\/a>). \u3055\u3089\u306b\uff0c\u30b7\u30b0\u30ca\u30eb\u5206\u5b50 PI3K \u304a\u3088\u3073 mTor \u306b\u3088\u308b\u5316\u5b66\u7684\u963b\u5bb3\u304a\u3088\u3073\u4f4e\u5206\u5b50\u5e72\u6e09 RNA (siRNA) \u3067\u306e Akt1 \u3092\u30ce\u30c3\u30af\u30c0\u30a6\u30f3 (silencing) \u306f\u72ec\u7acb\u3057\u3066\u5341\u5206\u306b LIF \u3092\u30c0\u30a6\u30f3\u30ec\u30ae\u30e5\u30ec\u30fc\u30c8\u3057\u305f\uff0e\u3055\u3089\u306b\uff0cLIF \u306f\u30d2\u30c8\u7b4b\u82bd\u7d30\u80de\u5897\u6b96\u3092\u523a\u6fc0\u3057\uff0c\u30d2\u30c8\u7b4b\u7ba1\u7d30\u80de\u3067\u306e jun-B \u304a\u3088\u3073 C-Mic \u767a\u73fe\u3092\u8a98\u5c0e\u3057\u305f\uff0e\u5bfe\u7167\u7684\u306b\uff0cLIF \u53d7\u5bb9\u4f53 \u306e siRNA \u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u306f\u5897\u6b96\u3092\u6e1b\u5c11\u3055\u305b\u308b\u7d50\u679c\u3068\u306a\u3063\u305f\uff0e\u3053\u308c\u3089\u306e\u77e5\u898b\u304b\u3089\uff0cLIF \u306f\u53ce\u7e2e\u8a98\u767a\u6027\u306e\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u3067\u3042\u308a\uff0c\u30aa\u30fc\u30c8\u30af\u30e9\u30a4\u30f3\u304b\u3064\u307e\u305f\u306f\u30d1\u30e9\u30af\u30e9\u30a4\u30f3\u69d8\u5f0f\u3067\u305d\u306e\u52b9\u679c\u3092\u767a\u63ee\u3057\u3066\u30b5\u30c6\u30e9\u30a4\u30c8\u7d30\u80de\u5897\u6b96\u3092\u8a98\u5c0e\u3059\u308b\u3068\u793a\u5506\u3055\u308c\u3066\u3044\u308b\uff0e<\/p>\n \u3000IL-15 \u306f IL-2 \u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3057\uff0c\u30d2\u30c8\u9aa8\u683c\u7b4b\u3067\u767a\u73fe\u3059\u308b\uff0e\u305d\u306e\u9aa8\u683c\u7b4b\u3067\u306e\u30a2\u30ca\u30dc\u30ea\u30c3\u30af\u52b9\u679c\u306b\u52a0\u3048\u3066\uff0cIL-15 \u306f\u8102\u8cea\u4ee3\u8b1d\u3067\u306e\u5f79\u5272\u3092\u6709\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b (97<\/a>). IL-15 \u306f\u524d\u8102\u80aa\u7d30\u80de\u3067\u306e\u8102\u8cea\u6c88\u7740\u3092\u6e1b\u5c11\u3055\u305b\uff0c\u8102\u80aa\u7d44\u7e54\u5168\u4f53\u306e\u8cea\u91cf\u3092\u6e1b\u5c11\u3055\u305b\u308b (98<\/a>,99<\/a>). \u7d50\u679c\u3068\u3057\u3066\uff0c\u30d2\u30c8\u306b\u304a\u3044\u3066\u306f IL-15 \u6fc3\u5ea6\u3068\u7dcf\u8102\u80aa\u91cf\uff0c\u4f53\u8102\u80aa\u7d44\u7e54\u91cf\u304a\u3088\u3073\u4f53\u8102\u80aa\u7387\u3068\u306e\u9593\u306b\u8ca0\u306e\u76f8\u95a2\u304c\u898b\u51fa\u3055\u308c\u305f (100<\/a>). <\/p>\n \u3000\u904b\u52d5\u4e0d\u8db3\u306f\u7b4b\u8089\u91cf\u55aa\u5931\u3068\u5185\u81d3\u8102\u80aa\u306e\u84c4\u7a4d\u306b\u3064\u306a\u304c\u308a\uff0c\u3044\u304f\u3064\u304b\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306f IL-15 \u304c\u8179\u90e8\u80a5\u6e80\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u6307\u6458\u3057\u3066\u3044\u308b\uff0e\u305d\u308c\u3092\u652f\u6301\u3059\u308b\u3088\u3046\u306b\uff0c\u6211\u3005\u306f\u30cd\u30ba\u30df\u306e\u7b4b\u8089\u306b\u304a\u3044\u3066 IL-15 \u304c\u904e\u5270\u767a\u73fe\u3057\u3066\u3044\u308b\u969b\u306b\u306f\u76ae\u4e0b\u8102\u80aa\u3067\u306a\u304f\u5185\u81d3\u8102\u80aa\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u3092\u8a3c\u660e\u3057\u305f (100<\/a>). \u3057\u304b\u3057\uff0cIL-15 \u306f\u8102\u80aa-\u7b4b\u8089\u9593\u306e\u30af\u30ed\u30b9\u30c8\u30fc\u30af\u306b\u304a\u3044\u3066\u4e00\u90e8\u306e\u5f79\u5272\u3092\u6f14\u3058\u3066\u3044\u308b\u3053\u3068\u306f\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u304c\uff0c\u7b4b\u7d30\u80de\u304b\u3089\u306e IL-15 \u5206\u6ccc\u306f\u8a18\u8ff0\u3055\u308c\u3066\u304a\u3089\u305a\uff0c\u3086\u3048\u306b\uff0cIL-15 \u3092\u771f\u306e\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u3068\u3057\u3066\u5206\u985e\u3059\u308b\u306b\u306f\u6642\u671f\u5c1a\u65e9\u3067\u3042\u308b\uff0e<\/p>\n \u3000\u9aa8\u683c\u7b4b\u7279\u7570\u7684\u306a\u4e16\u4ee3\u306f\uff0cAkt1 \u8a98\u5c0e\u578b\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30de\u30a6\u30b9\uff0c\u3064\u307e\u308a Akt1 \u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u306e\u30b9\u30a4\u30c3\u30c1\u3092\u30aa\u30f3\u30aa\u30d5\u3059\u308b\u3053\u3068\u3067\u53ef\u9006\u7684\u306b\u6a5f\u80fd\u3059\u308b II \u578b\u7b4b\u7dda\u7dad\u306b\u6210\u9577\u3067\u304d\u308b\u306e\u3067\u3042\u308b\u304c\uff0c\u65b0\u3057\u3044\u7b4b\u5206\u6ccc\u56e0\u5b50\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u305f (101<\/a>). \u5f7c\u3089\u306f\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3\u95a2\u9023\u86cb\u767d 1 \u304a\u3088\u3073 FGF-21 (104<\/a>) \u3092\u8a98\u5c0e\u3057\uff0c\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3\u95a2\u9023\u86cb\u767d 1 \u306f\u5fc3\u8840\u7ba1\u4fdd\u8b77\u52b9\u679c\u3092\u6709\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3042\u3063\u305f (102<\/a>,103<\/a>). \u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3\u95a2\u9023\u86cb\u767d 1 \u306f\uff0c\u4e00\u9178\u5316\u7a92\u7d20\u5408\u6210\u9175\u7d20\u4f9d\u5b58\u6027\u306e\u6a5f\u5e8f\u3092\u901a\u3058\u3066\u5185\u76ae\u7d30\u80de\u6a5f\u80fd\u304a\u3088\u3073\u865a\u8840\u7d44\u7e54\u306e\u518d\u704c\u6d41\u3092\u6d3b\u6027\u5316\u3059\u308b (102<\/a>). \u30d2\u30c8\u3067\u306e\u7814\u7a76\u304c\u652f\u6301\u3059\u308b\u3068\u3053\u308d\u306b\u3088\u308b\u3068\uff0cFGF-21 \u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u306b\u3088\u308a\u30a2\u30c3\u30d7\u30ec\u30ae\u30e5\u30ec\u30fc\u30c8\u3055\u308c\u308b\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u3067\u3042\u308b (105<\/a>). \u4ed6\u306e\u7b4b\u7d30\u80de\u7531\u6765\u86cb\u767d\u8cea\u306b\u306f BDNF (106<\/a>), \u30ab\u30eb\u30d7\u30ed\u30c6\u30af\u30c1\u30f3 (107<\/a>), \u30a8\u30ea\u30b9\u30ed\u30dd\u30a4\u30a8\u30c1\u30f3 (108<\/a>) \u304a\u3088\u3073 IL-4 \u304c\u542b\u307e\u308c\u3066\u304a\u308a\uff0cIL-4 \u306f\u7b4b\u82bd\u7d30\u80de\u306e\u7b4b\u7dda\u7dad\u3078\u306e\u878d\u5408\u3092\u523a\u6fc0\u3057\u3066\u7b4b\u518d\u751f\u3092\u4fc3\u9032\u3059\u308b (109<\/a>). <\/p>\n \u3000\u7b4b\u8089-\u9aa8\u76f8\u4e92\u4f5c\u7528\u306b\u304a\u3051\u308b\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u306e\u5f79\u5272\u306f\uff0c\u4e8c\u3064\u306e\u3088\u304f\u77e5\u3089\u308c\u305f\u9aa8\u65b0\u751f\u56e0\u5b50\u3067\u3042\u308b IGF-1 \u304a\u3088\u3073 FGF-2 \u304c\u30db\u30e2\u30b8\u30ca\u30a4\u30ba\u3055\u308c\u305f\u7b4b\u7d44\u7e54\u3067\u8c4a\u5bcc\u306b\u5b58\u5728\u3059\u308b\u3053\u3068\uff0c\u304a\u3088\u3073 in vitro \u3067\u57f9\u990a\u3055\u308c\u305f\u7b4b\u7dda\u7dad\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u3053\u3068\u3092\u5143\u306b\u3057\u3066\u793a\u5506\u3055\u308c\u3066\u3044\u305f (110<\/a>). \u3053\u308c\u3089\u306e\u6210\u9577\u56e0\u5b50\u306e\u53d7\u5bb9\u4f53\u306f\u7b4b\u8089\u3068\u9aa8\u306e\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30fc\u30b9\u3068\u3057\u3066\u9aa8\u819c\u306b\u5c40\u5728\u3057\u3066\u304a\u308a (111<\/a>), IGF-1 \u304a\u3088\u3073 FGF-21 \u304c\u7b4b\u8089-\u9aa8\u306e\u30af\u30ed\u30b9\u30c8\u30fc\u30af\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\uff0e<\/p>\n \u3000\u904e\u53bb\u6570\u5e74\u9593\u3067\uff0c\u30a2\u30a4\u30ea\u30b7\u30f3\u304c\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u3068\u3057\u3066\u767a\u898b\u3055\u308c\u305f\uff0e\u3053\u308c\u306f\u767d\u8272\u8102\u80aa\u7d44\u7e54\u3092\u8910\u8272\u8102\u80aa\u69d8\u306b\u5206\u5316\u3055\u305b\u308b\u3082\u306e\u3067\u3042\u308b\uff0ePCG-1α \u306e\u7b4b\u8089\u3067\u306e\u767a\u73fe\u306f FNDC5 \u306e\u767a\u73fe\u306e\u5897\u52a0\u3092\u793a\u3057\u3066\u304a\u308a\uff0c\u305d\u308c\u306f\u5207\u65ad\u3055\u308c\u30a2\u30a4\u30ea\u30b7\u30f3\u3068\u3057\u3066\u5206\u6ccc\u3055\u308c\u305f\u819c\u86cb\u767d\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u308b (112<\/a>). FNDC5 \u3092\u767a\u73fe\u3057\u305f\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u7c92\u5b50\u3092\u6ce8\u5c04\u3057\u305f\u30de\u30a6\u30b9\u3067\u306f\uff0c\u305d\u308c\u306b\u3088\u308a\u30a2\u30a4\u30ea\u30b7\u30f3\u6fc3\u5ea6\u304c 3 \u500d\u304b\u3089 4 \u500d\u306b\u5897\u52a0\u3057\uff0c\u767d\u8272\u8102\u80aa\u7d44\u7e54\u306e\u8910\u8272\u8102\u80aa\u7d30\u80de\u3078\u306e\u5206\u5316\u30d7\u30ed\u30b0\u30e9\u30e0\u304c\u8a98\u5c0e\u3055\u308c\uff0c\u4ed8\u968f\u3057\u3066\u30a8\u30cd\u30eb\u30ae\u30fc\u652f\u51fa\u304c\u5897\u52a0\u3059\u308b\u7d50\u679c\u3068\u306a\u308b\uff0e\u30d2\u30c8\u3067\u306f 10 \u9031\u9593\u306e\u898f\u5247\u7684\u306a\u904b\u52d5\u3067\u8840\u6e05\u30a2\u30a4\u30ea\u30b7\u30f3\u6fc3\u5ea6\u306e\u57fa\u790e\u5024\u304c\u5897\u52a0\u3057\uff0c\u3053\u308c\u306f\u904b\u52d5\u3078\u306e\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u9069\u5fdc\u306b\u304a\u3051\u308b\u30a2\u30a4\u30ea\u30b7\u30f3\u306e\u5f79\u5272\u3092\u793a\u5506\u3057\u3066\u3044\u308b (112<\/a>). <\/p>\n \u3000\u30d2\u30c8\u306e\u907a\u4f1d\u5b50\u914d\u5217\u306e 10 % \u307e\u3067\u304c\u86cb\u767d\u8cea\u3092\u767a\u73fe\u3059\u308b\u80fd\u529b\u304c\u3042\u308a\uff0c\u6f5c\u5728\u7684\u306b\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\uff0e\u305d\u306e\u3088\u3046\u306a\u5206\u6ccc\u56e0\u5b50\u306f\u7d30\u80de\u9593\u306e\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u306b\u95a2\u9023\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\uff0c\u8907\u96d1\u306a\u751f\u547d\u4f53\u306b\u304a\u3051\u308b\u6052\u5e38\u6027\u304c\u8981\u6c42\u3055\u308c\u308b (22<\/a>). \u591a\u304f\u306e\u7814\u7a76\u73ed\u304c\u7b4b\u7d30\u80de\u30bb\u30af\u30ec\u30c8\u30fc\u30e0\u306e\u540c\u5b9a\u306b\u5bc4\u4e0e\u3057\u3066\u304d\u305f\uff0eBortoluzzi \u3089\u306f\u6b63\u5e38\u306a\u30d2\u30c8\u9aa8\u683c\u7b4b\u7d30\u80de\u304b\u3089 6,255 \u306e\u907a\u4f1d\u5b50\u767a\u73fe\u7523\u7269\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3057\u305f (17<\/a>). \u5f7c\u3089\u306f\u9aa8\u683c\u7b4b\u306e\u30bb\u30af\u30ec\u30c8\u30fc\u30e0\u306f 319 \u306e\u86cb\u767d\u8cea\u3092\u542b\u3080\u3068\u306e\u63a8\u5b9a\u306b\u81f3\u308a\uff0c\u305d\u308c\u306b\u306f 78 \u306e\u307e\u3060\u6027\u8cea\u306e\u5206\u304b\u3063\u3066\u3044\u306a\u3044\u86cb\u767d\u8cea\u3082\u542b\u307e\u308c\u3066\u3044\u308b\uff0eYoon \u3089\u306f\u5206\u5316\u3057\u305f L6 \u30e9\u30c3\u30c8\u9aa8\u683c\u7b4b\u7d30\u80de\u3092\u7814\u7a76\u3057\u3066\u5168\u90e8\u3067 254 \u306e\u86cb\u767d\u8cea\u3092\u540c\u5b9a\u3057\uff0c\u305d\u306e\u3046\u3061 153 \u304c\u5206\u6ccc\u86cb\u767d\u8cea\u3067\u3042\u308b\u3068\u5206\u985e\u3055\u308c\u305f (18<\/a>). Henningsen \u3089\u306e\u7814\u7a76\u3067\u306f\uff0c\u5b9a\u91cf\u7684\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u304c\u4f7f\u7528\u3055\u308c\uff0c\u30de\u30a6\u30b9 C2C12 \u9aa8\u683c\u7b4b\u7d30\u80de\u306e\u5206\u5316\u306e\u9593\u306b\u5206\u6ccc\u3055\u308c\u308b\u56e0\u5b50\u3092\u8abf\u67fb\u3057\u305f\uff0e\u5168\u90e8\u3067 635 \u306e\u5206\u6ccc\u86cb\u767d\u8cea\u304c\u540c\u5b9a\u3055\u308c\u305f (19<\/a>). \u86cb\u767d\u8cea\u306e CC \u30b1\u30e2\u30ab\u30a4\u30f3\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u4e00\u54e1\u306f\u5206\u5316\u306e\u9593\u306e\u5206\u6ccc\u306b\u304a\u3044\u3066\u975e\u5e38\u306b\u660e\u78ba\u306a\u30d1\u30bf\u30fc\u30f3\u3092\u793a\u3057\u305f (113<\/a>). Norheim \u3089\u306f\u5168\u90e8\u3067 236 \u306e\u86cb\u767d\u8cea\u304c\u57f9\u990a\u30d2\u30c8\u7b4b\u7dda\u7dad\u306e\u6761\u4ef6\u4ed8\u304d\u57f9\u5730\u306b\u304a\u3051\u308b\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\u89e3\u6790\u306b\u304a\u3044\u3066\u691c\u51fa\u3055\u308c\u305f\u3068\u8a3c\u660e\u3057\u305f (114<\/a>). \u5065\u5eb7\u306a\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\u306b 11 \u9031\u9593\u306e\u7b4b\u529b\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u308f\u305b\u305f\u5f8c\uff0c\u5916\u5074\u5e83\u7b4b\u304a\u3088\u3073\u307e\u305f\u306f\u50e7\u5e3d\u7b4b\u3067 15 \u306e\u7b4b\u5206\u6ccc\u86cb\u767d\u8cea\u304c mRNA \u767a\u73fe\u3092\u8457\u660e\u306b\u5897\u52a0\u3055\u305b\u3066\u3044\u305f\u3053\u3068\u304c RT-PCR \u89e3\u6790\u306b\u3088\u308a\u8a3c\u660e\u3055\u308c\u305f\uff0e<\/p>\n \u3000\u540c\u5b9a\u3055\u308c\u305f\u591a\u304f\u306e\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u306f\u305d\u306e\u52b9\u679c\u3092\u7b4b\u8089\u81ea\u8eab\u306e\u4e2d\u3067\u767a\u63ee\u3059\u308b\uff0e\u3086\u3048\u306b\uff0c\u30df\u30aa\u30b9\u30bf\u30c1\u30f3\uff0cLIF, IL-4, IL-6, IL-7 \u304a\u3088\u3073 IL-15 \u306f\u7b4b\u80a5\u5927\u3068\u7b4b\u5f62\u6210\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\uff0eBDNF \u304a\u3088\u3073 IL-6 \u306fAMPK \u5a92\u4ecb\u6027\u8102\u8cea\u9178\u5316\u306b\u95a2\u9023\u3057\u3066\u304a\u308a\uff0cIL-8 (CXCL-1) \u306f\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u8a98\u767a\u6027\u8840\u7ba1\u65b0\u751f\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\uff0e\u3057\u304b\u3057\uff0cIL-6 \u306f\u307e\u305f\u5168\u8eab\u52b9\u679c\u3092\u3082\u793a\u3057\uff0c\u305d\u308c\u306b\u306f\u809d\u81d3\uff0c\u8102\u80aa\u7d44\u7e54\u304a\u3088\u3073\u514d\u75ab\u7cfb\u304c\u542b\u307e\u308c\u308b\uff0e\u30d5\u30a9\u30ea\u30b9\u30bf\u30c1\u30f3\u95a2\u9023\u86cb\u767d 1 \u306f\u5185\u76ae\u7d30\u80de\u6a5f\u80fd\u3068\u865a\u8840\u30b9\u30c8\u30ec\u30b9\u72b6\u614b\u4e0b\u3067\u306e\u518d\u704c\u6d41\u3092\u4fc3\u9032\u3059\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u540c\u5b9a\u3055\u308c\u305f\uff0eIGF-1 \u3068 FGF-21 \u306f\u7b4b\u8089-\u9aa8\u306e\u30af\u30ed\u30b9\u30c8\u30fc\u30af\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\uff0e<\/p>\n \u3000\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u5206\u91ce\u306f\u65b0\u3057\u304f\uff0c\u304b\u3064\uff0c\u4eca\u65e5\u3067\u306f\uff0c\u30d2\u30c8\u306e\u7814\u7a76\u3067\u306f IL-6 \u306e\u5f79\u5272\u306b\u6700\u3082\u7126\u70b9\u304c\u5f53\u3066\u3089\u308c\u3066\u3044\u308b\uff0e\u7b4b\u7531\u6765\u306e IL-6 \u304c\u3044\u304f\u3064\u304b\u306e\u6709\u76ca\u306a\u4ee3\u8b1d\u52b9\u679c\u3092\u6709\u3059\u308b\u3068\u306e\u77e5\u898b\u306f\uff0c\u904b\u52d5\u4e0d\u8db3\u306e\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3068\u6162\u6027\u75be\u60a3\u306e\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3068\u306e\u95a2\u9023\u3092\u793a\u5506\u3057\u3066\u3044\u308b\uff0eSadagurski \u3089\u306f\uff0c\u30d2\u30c8 IL-6 \u306e\u5faa\u74b0\u8840\u4e2d\u6fc3\u5ea6\u304c\u6301\u7d9a\u7684\u306b\u9ad8\u5024\u3067\u3042\u308b\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30de\u30a6\u30b9\u306b\u304a\u3044\u3066\u4e2d\u5fc3\u6027\u30ec\u30d7\u30c1\u30f3\u4f5c\u7528\u304c\u4ea2\u9032\u3057\u3066\u304a\u308a\uff0c\u6804\u990a\u7d20\u306e\u6052\u5e38\u6027\u304c\u6539\u5584\u3057\u305f\u7d50\u679c\uff0c\u98df\u4e8b\u8a98\u767a\u6027\u80a5\u6e80\u304b\u3089\u306e\u4fdd\u8b77\u306b\u81f3\u3063\u305f\u3068\u8a3c\u660e\u3057\u305f (115<\/a>). \u3055\u3089\u306b\uff0cWunderlich \u3089\u306f\u30de\u30a6\u30b9\u3067\u306e\u6b63\u5e38\u306a\u809d\u81d3\u306e\u4ee3\u8b1d\u306b IL-6 \u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u304c\u5fc5\u8981\u3068\u3055\u308c\u308b\u3053\u3068\u3092\u793a\u3057\u305f\uff0e\u6ce8\u76ee\u3059\u3079\u304d\u306f\uff0c\u6bdb\u69d8\u4f53\u795e\u7d4c\u6804\u990a\u56e0\u5b50\u304c\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3 IL-6 \u30d5\u30a1\u30df\u30ea\u30fc\u306e\u4e00\u54e1\u3067\u3042\u308a\uff0c\u9ad8\u8102\u80aa\u98df (70<\/a>) \u3084\u8102\u8cea\u6ce8\u5c04\u3067\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u8a98\u767a\u3055\u308c\u305f\u30de\u30a6\u30b9\u3067\u3055\u3048\u4ee3\u8b1d\u306e\u6052\u5e38\u6027\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u3067\u3042\u308b (117<\/a>). \u8208\u5473\u6df1\u3044\u3053\u3068\u306b\uff0c\u6bdb\u69d8\u4f53\u795e\u7d4c\u6804\u990a\u56e0\u5b50\u306e\u5909\u7570\u4f53\u3067\u3042\u308b axokine \u306f\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3044\u3066 2 \u578b\u7cd6\u5c3f\u75c5\u6cbb\u7642\u306b\u7528\u3044\u3089\u308c\u305f\u304c\uff0c\u52b9\u679c\u3092\u4e2d\u548c\u3059\u308b\u6297\u4f53\u304c\u5b58\u5728\u3057\u306a\u3044\u3053\u3068\u3092\u7406\u7531\u306b\u627f\u8a8d\u3055\u308c\u306a\u304b\u3063\u305f (118<\/a>). \u306b\u3082\u304b\u304b\u308f\u3089\u305a\uff0c\u904b\u52d5\u304c\u8907\u6570\u306e\u6709\u76ca\u306a\u52b9\u679c\u3092\u6709\u3059\u308b\u3068\u306e\u77e5\u898b\u306f\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u306b\u3088\u308a\u5a92\u4ecb\u3055\u308c\u308b\u3082\u306e\u3067\u3042\u308a\uff0c\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u7814\u7a76\u306e\u6cbb\u7642\u306b\u304a\u3051\u308b\u6f5c\u5728\u7684\u306a\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\uff0e<\/p>\n \u3000AMPK \u6d3b\u6027\u5316\u3092\u7d4c\u7531\u3057\u3066\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u5468\u8fba\u306e\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u306e\u52b9\u679c\u3068\u306f\u5225\u306b\uff0c\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u304c\u81b5\u81d3 β \u7d30\u80de\u306e\u4ee3\u8b1d\u304a\u3088\u3073\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u306b\u304a\u3044\u3066\u4e3b\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u51fa\u73fe\u3057\u3066\u3044\u308b\uff0eBouzakri \u3089\u306f\u30d2\u30c8\u7b4b\u7dda\u7dad\u304c\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u306e\u7570\u306a\u308b\u30d1\u30cd\u30eb\u3092\u767a\u73fe\u3057\u653e\u51fa\u3057\uff0c\u305d\u308c\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306b\u4f9d\u5b58\u3057\u3066\u304a\u308a\uff0c\u305d\u308c\u305e\u308c\u306e\u30d1\u30cd\u30eb\u304c\u81b5\u81d3 β \u7d30\u80de\u306b\u304a\u3044\u3066\u7570\u306a\u308b\u52b9\u679c\u3092\u767a\u63ee\u3057\u3066\u3044\u308b\u3068\u793a\u3057\u305f (119<\/a>). \u3055\u3089\u306b\uff0cEllinsgaard \u3089\u306f\uff0c\u904b\u52d5\u304c\u6b63\u5e38\u30de\u30a6\u30b9\u3067\u306f\u8010\u7cd6\u80fd\u3092\u5897\u52a0\u3055\u305b\u308b\u4e00\u65b9\u3067\uff0c\u3053\u306e\u73fe\u8c61\u306f IL-6 \u5168\u6b20\u640d\u30de\u30a6\u30b9\u3067\u306f\u8d77\u3053\u3089\u306a\u3044\u3053\u3068\u3092\u793a\u3057\u305f (120<\/a>). \u3044\u304f\u3064\u304b\u306e\u512a\u79c0\u306a\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\uff0c\u7814\u7a76\u8005\u305f\u3061\u306f\u904b\u52d5\u8a98\u767a\u6027 GLP-1 \u53cd\u5fdc\u304c\u7b4b\u7531\u6765 IL-6 \u306b\u4f9d\u5b58\u3059\u308b\u3053\u3068\u3092\u793a\u3059\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u3063\u305f\uff0e\u3086\u3048\u306b\uff0cIL-6 \u306f\u4e8c\u3064\u306e\u7570\u306a\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u3082\u3064\u7d44\u7e54\u9593\u3067\u306e\u30af\u30ed\u30b9\u30c8\u30fc\u30af\u3092\u5a92\u4ecb\u3059\u308b\uff0e\u3064\u307e\u308a\u8178\u7ba1\u3068\u81b5\u5cf6\u3067\u3042\u308b\u304c\uff0cGLP-1 \u5206\u6ccc\u5897\u52a0\u306b\u3088\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u9700\u8981\u306e\u5909\u5316\u306b\u9069\u5fdc\u3059\u308b\u305f\u3081\u3067\u3042\u308b\uff0e<\/p>\n \u3000\u75ab\u5b66\u7814\u7a76\u306f\u5973\u6027\u306e\u5ea7\u4f4d\u306e\u751f\u6d3b\u30b9\u30bf\u30a4\u30eb\u3067\u306e\u4e73\u764c\u30ea\u30b9\u30af\u5897\u5927\u3092\u793a\u5506\u3057\u3066\u304a\u308a\uff0c\u4e00\u65b9\u3067\u898f\u5247\u7684\u306a\u904b\u52d5\u306f\u4e73\u764c\u306e\u9032\u884c\u306b\u5bfe\u3057\u3066\u4fdd\u8b77\u52b9\u679c\u304c\u3042\u308b (121<\/a>). \u904b\u52d5\u304c\u4e73\u764c\u7d30\u80de\u5897\u6b96\u3092\u963b\u5bb3\u3059\u308b\u4f55\u3089\u304b\u306e\u52b9\u679c\u3092\u4e00\u3064\u307e\u305f\u306f\u3044\u304f\u3064\u304b\u306e\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u304c\u5a92\u4ecb\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u5b58\u5728\u3057\uff0c\u53ef\u80fd\u6027\u306e\u3042\u308b\u5019\u88dc\u306f\u30aa\u30f3\u30b3\u30b9\u30bf\u30c1\u30f3 M \u3067\u3042\u308a\uff0cIl-6 \u30b9\u30fc\u30d1\u30fc\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u4e00\u54e1\u3067\u3042\u308b (122<\/a>). <\/p>\n \u3000\u8981\u7d04\u3059\u308b\u3068\uff0c\u904b\u52d5\u4e0d\u8db3\u3068\u7b4b\u5ec3\u7528\u306f\u7b4b\u8089\u91cf\u55aa\u5931\u3068\u5185\u81d3\u8102\u80aa\u7d44\u7e54\u306e\u84c4\u7a4d\u306b\u81f3\u308a\uff0c\u305d\u306e\u7d50\u679c\u3068\u3057\u3066\u708e\u75c7\u6027\u7d4c\u8def\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u6d3b\u6027\u5316\u3055\u305b\uff0c\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\uff0c\u52d5\u8108\u786c\u5316\uff0c\u795e\u7d4c\u5909\u6027\u3068\u816b\u760d\u5897\u5927\u3092\u4fc3\u9032\u3057\uff0c\u3086\u3048\u306b\uff0c\u6162\u6027\u75be\u60a3\u306e\u30af\u30e9\u30b9\u30bf\u30fc\u306e\u9032\u5c55\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u306b\u306a\u308b (Figure 3<\/strong>) (21<\/a>). \u5bfe\u7167\u7684\u306b\uff0c\u7b4b\u8089\u304c\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u7523\u751f\u3057\u653e\u51fa\u3059\u308b\u3068\u306e\u77e5\u898b\u306f\uff0c\u904b\u52d5\u304c\u3044\u304b\u306b\u3057\u3066\u65e9\u671f\u6b7b\u4ea1\u304b\u3089\u4fdd\u8b77\u3059\u308b\u304b\u306e\u7406\u89e3\u306b\u3064\u3044\u3066\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u57fa\u790e\u3092\u63d0\u4f9b\u3057\u3066\u3044\u308b (Figure 4<\/strong>). <\/p>\n \u3000\u7b4b\u8089\u306f\u4f53\u5185\u3067\u6700\u5927\u306e\u81d3\u5668\u3067\u3042\u308b\u3053\u3068\u304b\u3089\uff0c\u7b4b\u8089\u306e\u30bb\u30af\u30ec\u30c8\u30fc\u30e0\u306e\u540c\u5b9a\u306f\u79d1\u5b66\u306e\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\u306b\u3068\u3063\u3066\u65b0\u3057\u3044\u8b70\u984c\u306e\u8a2d\u5b9a\u3092\u53ef\u80fd\u306b\u3057\u305f\uff0e\u9aa8\u683c\u7b4b\u306f\u5206\u6ccc\u81d3\u5668\u3067\u3042\u308b\u3068\u306e\u89b3\u70b9\u306f\uff0c\u7b4b\u8089\u304c\u3044\u304b\u306b\u3057\u3066\u4ed6\u306e\u81d3\u5668\uff0c\u3064\u307e\u308a\u8102\u80aa\u7d44\u7e54\uff0c\u809d\u81d3\uff0c\u81b5\u81d3\uff0c\u9aa8\u304a\u3088\u3073\u8133\u3068\u5bfe\u8a71\u3059\u308b\u304b\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306e\u6982\u5ff5\u7684\u57fa\u790e\u3092\u63d0\u4f9b\u3057\u3066\u304f\u308c\u308b\uff0e\u904b\u52d5\u4e0d\u8db3\u3084\u7b4b\u8089\u3092\u4f7f\u7528\u3057\u306a\u3044\u3053\u3068\u306f\u6f5c\u5728\u7684\u306b\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u53cd\u5fdc\u306e\u969c\u5bb3\u3084\u5909\u5316\u306b\u3044\u305f\u308a\uff0c\u304b\u3064\u307e\u305f\u306f\u30de\u30a4\u30aa\u30ab\u30a4\u30f3\u62b5\u6297\u6027\u306f\uff0c\u306a\u305c\u904b\u52d5\u306e\u6b20\u843d\u304c\u5fc3\u8840\u7ba1\u75be\u60a3\uff0c2 \u578b\u7cd6\u5c3f\u75c5\uff0c\u816b\u760d\u304a\u3088\u3073\u9aa8\u7c97\u9b06\u75c7\u3092\u542b\u3080\u75be\u75c5\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u5168\u4f53\u306e\u30ea\u30b9\u30af\u3092\u5897\u3084\u3059\u306e\u304b\u3092\u8aac\u660e\u3059\u308b\uff0e<\/p>\n 1. 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Exercise-induced musclederived cytokines inhibit mammary cancer cell growth. Am. J. Physiol. Endocrinol. Metab. 301, E504\u2013E510 (2011).<\/p>\n","protected":false},"excerpt":{"rendered":" \u3000NHK \u30b9\u30da\u30b7\u30e3\u30eb\u300c\u4eba\u4f53\u300d\u30b7\u30ea\u30fc\u30ba\u7b2c 2 \u96c6\u300c\u9a5a\u304d\u306e\u30d1\u30ef\u30fc\uff01\u201c\u8102\u80aa\u3068\u7b4b\u8089\u201d\u304c\u547d\u3092\u5b88\u308b\u300d\u3067\u7d39\u4ecb\u3055\u308c\u3066\u3044\u305f\u8ad6\u6587\u3067\u3042\u308b\uff0e\u7b4b\u8089\u3082\u307e\u305f\u69d8\u3005\u306a\u30e1\u30c3\u30bb\u30fc\u30b8\u7269\u8cea\u3092\u51fa\u3057\u3066\u4f53\u5185\u306e\u81d3\u5668\u3068\u5bfe\u8a71\u3057\u3066\u3044\u308b\u5206\u6ccc\u81d3\u5668\u3067\u3042\u308b\uff0c\u3068\u3044\u3046\u8996\u5ea7\u3092\u63d0\u4f9b\u3057\u305f\u70b9\u3067\u3053 … <\/p>\n![\"\"](\"https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/07\/Pende-Pedersen-1024x576.png\")
<\/a>Muscles, exercise and obesity: skeletal muscle as a secretory organ<\/a> Nature Reviews Endocrinology volume 8, pages 457\u2013465 (2012)<\/h3>\n
Abstract<\/h3>\n
Introduction<\/h3>\n
![\"\"](\"https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/07\/nrendo.2012.49-f1.jpg\")
<\/a>
balance. Especially under conditions of obesity, adipose tissue secretes
adipokines, which contribute to establish a chronic inflammatory environment that promotes pathological processes such as atherosclerosis and insulin resistance. Skeletal muscles are capable of producing myokines that confer some of the health benefits of exercise. Such myokines might counteract the harmful effects of proinflammatory adipokines.<\/figcaption><\/figure>\n![\"\"](\"https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/07\/nrendo.2012.49-f2.jpg\")
<\/a>Myostatin<\/h3>\n
IL\u20116<\/h3>\n
IL\u20117<\/h3>\n
IL\u20118 and CXCL\u20111<\/h3>\n
LIF<\/h3>\n
IL\u201115<\/h3>\n
Other myokines<\/h3>\n
Bioinformatics and proteomic studies<\/h3>\n
Myokines: clinical aspect<\/h3>\n
![\"\"](\"https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/07\/nrendo.2012.49-f3.jpg\")
<\/a>![\"\"](\"https:\/\/www.muscle-hypertrophy.com\/wp-content\/uploads\/2018\/07\/nrendo.2012.49-f4.jpg\")
<\/a>Conclusions<\/h3>\n
References<\/h3>\n